谢斯滔
- 电子邮件：xiesitao@him.cas.cn
个人简历
谢斯滔，中国科学院杭州医学研究所特聘研究员，作为课题组长与研究骨干分别参与国家重点研发计划前沿生物技术专项与合成生物学专项，先后主持国家自然科学基金青年、面上项目、浙江省自然科学基金重大项目和参与多项国家级科研项目。主要研究方向包括：1）功能核酸发现、设计、改造等前沿技术探索研究；2）mRNA药物、疫苗技术创新与转化应用研究。迄今在SCI收录期刊发表学术论文40余篇，其中以第一作者/通讯作者身份分别在Chem.,Nat. Commun.,J. Am. Chem. Soc.,Angew. Chem. Int. Ed.等期刊发表学术论文，获授权国家发明专利十余项。
研究方向
1）功能核酸发现、设计、改造等前沿技术探索研究；
2）mRNA药物、疫苗技术创新与转化应用研究。
承担科研项目情况
作为课题组长与研究骨干分别参与国家重点研发计划前沿生物技术专项与合成生物学专项，先后主持国家自然科学基金青年、面上项目、浙江省自然科学基金重大项目和参与多项国家级科研项目。
代表论著
[1] Kedan Gu, Ting Liang, Luting Hu, Yifan Zhao, Weiyang Ying, Mengke Zhang, Yashuang Chen, Benmeng Liang, Xinrui Lin, Yanqi Zhang, Hongyu Wu, Meng Wang, Yuping Zhu, Wenxi Wang, Yu Zhang, Chao Zuo, Zhen Du, Penghui Zhang, Jia Song, Liwen Li, Xiangsheng Liu*, Sitao Xie*, Weihong Tan*. "Intraperitoneal programming of tailored CAR macrophages via mRNA lipid nanoparticle to boost cancer immunotherapy." Nature Communications. 2026, 17, 941.
[2] Yulong Tang, Yuji Niu, Wenxi Wang, Beibei Wu, Jianmin Jiang, Xu Qian*, Yu Zhang*, Sitao Xie*, Weihong Tan. "Screening of short-chain IRES elements for enhanced circRNA translation efficiency." Science China Chemistry. 2025, 68 (12), 6439-6442.
[3] Yingyu Sima, Lili Ai, Linlin Wang, Pengge Zhang, Qiang Zhang, Shanchao Wu, Sitao Xie*, Zilong Zhao*, Weihong Tan*. "A DNA Molecular Logic Circuit for Precise Tumor Identification." Nano Letters. 2024, 24 (39), 12070-12079.
[4] Lili Ai, Qianqian Zuo, Youshan Li, Shanchao Wu, Yingyu Sima, Yutong Zhang, Sitao Xie*, Zilong Zhao*, Weihong Tan*. " Programming Affinity for Precise Tumor Recognition with Allosteric Nanosensing-Circles." ACS nano. 2023, 17 (14), 13430-13440.
[5] Zhen Du*, Xin Wang, Xiao Zhang, Zhanjun Gu, Xiaoyi Fu, Shaoju Gan, Ting Fu, Sitao Xie*, Weihong Tan*. " X-Ray-triggered Carbon Monoxide and Manganese Dioxide Generation based on Scintillating Nanoparticles for Cascade Cancer Radiosensitization." Angewandte Chemie International Edition. 2023, 62 (23), e202302525.
[6] Sitao Xie, Weidi Sun, Ting Fu, Xiangsheng Liu, Peng Chen, Liping Qiu* Fengli Qu and Weihong Tan*. " Aptamer-based targeted delivery of functional nucleic acids." Journal of the American Chemical Society. 2023, 145 (14), 7677-7691.
[7] Yuan Liu, Xu Qian, Chunyan Ran, Longjie Li, Ting Fu, Dan Su, Sitao Xie*, Weihong Tan*. " Aptamer-Based Targeted Protein Degradation." ACS nano. 2023, 17 (7), 6150-6164.
[8] Jing Zhang, Dan Wang, Hong Chen, Xi Yuan, Xinyi Jiang, Lili Ai, Jiaxuan He, Fengming Chen, Sitao Xie*, Cheng Cui*, Weihong Tan*. "Nanoscale Device Enhancing Temporal and Force Stability for Specific Tumor Imaging." Nano Letters, 2022, 22 (23), 9441-9449.
[9] Zhimin Wang, Sitao Xie*, Limei Wu, Fengming Chen, Liping Qiu* and Weihong Tan*. " Aptamer-Functionalized Nanodevices for Dynamic Manipulation of Membrane Receptor Signaling in Living Cells. " Nano letters, 2022, 22 (19), 7853-7859.
获奖及荣誉
获授权国家发明专利十余项。
