研究员，国家级青年人才项目入选者，华中农业大学农业微生物国家重点实验室神经病毒学博士，斯坦福大学医学院眼科系博士后，Instructor（讲师），中国科学院杭州医学研究所眼科研究中心青年领军人才，博士生/博士后导师。研究工作聚焦在视神经损伤，青光眼等神经退行性疾病等课题，主要致力于视神经再生因子的筛选，视神经节细胞在退行性疾病中的功能成像及治疗后的功能评价，视神经修复的分子机理探索等相关方向的研究。以第一作者和共同通讯作者在Science Translational Medicine，Neuron，PNAS，eLife，Brain structure and function和Journal of medical virology等期刊发表研究论文26篇。筛选的视神经修复及再生因子申请国际发明专利2项。

课题组主页：https://www.x-mol.com/groups/Eye2Brain-reLink

1）视神经损伤后再生及眼脑通路重建工作，包括且不限于视神经修复和再生因子的筛选、视神经变性相关分子通路和机理探索、；

2）单细胞水平视感光细胞（视锥细胞和视杆细胞，PRs）、双极细胞（BCs）、视网膜神经节细胞（RGC）、视网膜小胶质细胞（retinal MGs）、大脑上丘神经元（SC neurons）长期在体功能学成像，包括但不限于光激活或疾病损伤下的钙离子、氧化应激、ATP等功能成像；

3）高眼压青光眼疾病的分子机理探索及治疗因子的筛选，包括且不限于核酸适配体药物（Aptamer）、抗体类药物、多肽类药物、小分子化合物药物等；

4）干性黄斑变性Dry-AMD的治疗药物筛选。

国家自然科学基金优秀青年科学基金（海外）项目

1. Liang Li, Xue Feng, Fang Fang, Jinyu Fei, Jenny Lu, Huiying Zhang, Michaela Ždímalová, YuanYuan, Ziming Luo, Haoliang Huang, Dong Liu, Fengwen Huang, Hao Liu, Yuyang Zeng, Fuyun Bian, Mingshen Ma, In-jee You, Liang Liu, Xiaoqin Yan, Mu Li, Yan Lin, Qinghong Xie, Arjun, Krish, Xin Duan, Jeffrey Louis Goldberg, Xiaoke Chen, Marcus Braun, Lánský Zdeněk, Ying Han, Ruobo Zhou, Yang Hu. F-actin depolymerization mediates neuro-repair of traumatic and glaucomatous degeneration via promoting mitochondria mobile. Science Translational Medicine. 2026. 18. Eadw(0908).

2. Liang Li, Fang Fang, Xue Feng, Pei Zhuang, Haoliang Huang, Pingting Liu, Liang Liu, Adam Z. Xu, Lei S. Qi, Le Cong, Yang Hu. Single Cell Transcriptome Analysis of Regenerating RGCs Reveals Potent Glaucoma Neural Repair Genes. Neuron. 2022. 110, 2646-2663.   

3. Liang Li, Xue Feng, Fang Fang, David Andrew Miller, Shaobo Zhang, Pei Zhuang, Haoliang Huang, Pingting Liu, Junting Liu, Nripun Sredar, Liang Liu, Yang Sun, Xin Duan, Jeffrey L Goldberg, Hao F Zhang, Yang Hu. Longitudinal in vivo Ca2+ imaging reveals dynamic activity changes of diseased retinal ganglion cells at the single-cell level. Proceedings of the National Academy of Sciences (PNAS). 2022. 119, e2206829119. 

4. Liang Li, Yajie Tang, Leqiang Sun, Jinsong Yu, Siheng Zhang, Hui Gong, Hannah C Webber, Xiaoyu Zhang, Zhe Hu, Xiangning Li, Khaista Rahman, Xiangwei Shi, Zhenfang Fu, Jinxia Dai, Gang Cao. Delineating the organization of projection neuron subsets in primary visual cortex with multiple fluorescent rabies virus tracing. Brain Structure and Function. 2021. 226(4) 951-961.  

5. Liang Li, Haoliang Huang, Fang Fang, Liang Liu, Yang Sun, Yang Hu. Longitudinal morphological and functional assessment of RGC neurodegeneration after optic nerve crush in mouse. Frontiers in cellular neuroscience. 2020. 14(109).  

6. Jie Zhang*, Liang Li*(co-first author), Haoliang Huang, Fang Fang, Hannah C Webber, Pei Zhuang, Liang Liu, Roopa Dalal, Peter H Tang, Vinit B Mahajan, Yang Sun, Shaohua Li, Mingchang Zhang, Jeffery L Goldberg, Yang Hu. Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse. Elife. 2019. 8, e45881.

7. Leqiang Sun, Meiling Zhou, Chuangang Liu, Yajie Tang, Ke Xiao, Jinxia Dai, Zhisong Gao, Leonard Siew, Gang Cao, Xiang Wu, Liang Li † (co-corresponding author), Ran Zhang †. Memantine can relieve the neuronal impairment caused by neurotropic virus infection. Journal of medical virology. 2019. 91 (6), 935-940. (IF=12.7)

8. Yajie Tang, Liang Li, Leqiang Sun, Jinsong Yu, Zhe Hu, Kaiqi Lian, Gang Cao, Jinxia Dai. In vivo two-photon calcium imaging in dendrites of rabies virus-labeled v1 corticothalamic neurons. Neuroscience bulletin. 2020. 36 (5), 545-553. (IF=5.6)