胡海
胡海,一级主任医师,二级教授,中国科学院杭州医学研究所研究员,浙江省肿瘤医院副院长,乳腺中心主任,国家杰出青年基金获得者,国务院特殊津贴专家,国家卫健委四大慢病项目首席科学家,国家重点研发项目首席科学家。长期从事肿瘤及肿瘤微环境代谢与治疗抵抗的转化研究。在Cell、Cancer Cell、Nature Communications、Clinical Cancer Research等期刊发表论文50余篇,获国内发明专利授权30余项。带领团队主导研发的13种肺癌相关抗体检测试剂盒(流式荧光免疫法),正式获得国家药监局三类医疗器械注册证,成为全球首个针对CT发现肺结节(尤其是小结节)良恶性鉴别的辅助诊断试剂盒,并有望显著提升肺癌早期诊断率。担任中国抗癌协会肿瘤异质性与个体化治疗委员会副主委(候任主委),中国抗癌协会代谢委员会常委。担任 Malignancy Spectrum(国家科协高起点期刊)副主编,Science Bulletin (科学通报)编委,Fundamental Research(国家基金委科学综合期刊)编委。
团队聚焦肿瘤代谢与靶向治疗转化研究,并在此基础上发展新型抗肿瘤治疗方法和药物及诊断试剂等,实现肿瘤精准医学诊治手段的新突破,目前多项研究成果已经在国内外实现转化。
1.科技部 国家任务/国家科技重大专项 肿瘤代谢重塑及其分子网络的时空调控机制研究,主持
2.科技部,重点研发计划,肿瘤发生发展多维组学时空网络研究与表型组解析,主持
3.国家自然科学基金杰出青年项目,主持
4.浙江省科学技术厅,尖兵领雁项目,恶性肿瘤精准治疗关键技术研究-用以指导保腋窝手术的乳腺癌前哨淋巴结转移预测多维组学人工智能模型研究,主持
1. Zhu, Y., Zhou, Z., Du, X., Lin, X., Liang, Z. M., Chen, S., Sun, Y., Wang, Y., Na, Z., Wu, Z., Zhong, J., Han, B., Zhu, X., Fu, W., Li, H., Luo, M. L., &Hu, H.(2025). Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion. Cancer cell, 43(6), 1045–1060.e7.
2. Zhou, Z., Zhu, Y., Zhao, J., Zhao, Y., Fu, W., Zhou, C., Hu, J., Zeng, Y., Lin, Y., An, H., Yin, H., Yao, H., & Hu, H. (2025). Dabrafenib upregulates hypoglycosylated MUC1 and improves the therapeutic efficacy of Tn-MUC1 CAR-T cells. Science bulletin, 70(10), 1586–1590.
3. Chen, J., Liu, X., Zou, Y., Gong, J., Ge, Z., Lin, X., Zhang, W., Huang, H., Zhao, J., Saw, P. E., Lu, Y., Hu, H., & Song, E. (2024). A high-fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and PMN-MDSC differentiation. Proceedings of the National Academy of Sciences of the United States of America, 121(20), e2306776121.
4. Zheng, F., Chen, J., Zhang, X., Wang, Z., Chen, J., Lin, X., Huang, H., Fu, W., Liang, J., Wu, W., Li, B., Yao, H., Hu, H., & Song, E. (2021). The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis. Nature communications, 12(1), 1341.
5. Li, Q., Qin, T., Bi, Z., Hong, H., Ding, L., Chen, J., Wu, W., Lin, X., Fu, W., Zheng, F., Yao, ., Luo, M. L., Saw, P. E., Wulf, G. M., Xu, X., Song, E., Yao, H., & Hu, H. (2020). Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer. Nature communications, 11(1), 1456.
6. Hu, H., Juvekar, A., Lyssiotis, C. A., Lien, E. C., Albeck, J. G., Oh, D., Varma, G., Hung, Y. P., Ullas, S., Lauring, J., Seth, P., Lundquist, M. R., Tolan, D. R., Grant, A. K., Needleman, D. J., Asara, J. M., Cantley, L. C., & Wulf, G. M. (2016). Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton. Cell, 164(3), 433–446.
7. Juvekar, A., Hu, H., Yadegarynia, S., Lyssiotis, C. A., Ullas, S., Lien, E. C., Bellinger, G., Son, J., Hok, R. C., Seth, P., Daly, M. B., Kim, B., Scully, R., Asara, J. M., Cantley, L. C., & Wulf, G. M. (2016). Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proceedings of the National Academy of Sciences of the United States of America, 113(30), E4338–E4347.
获教育部科学技术进步奖一等奖、教育部自然科学奖二等奖、广东省科技进步二等奖。