那振坤
- 电子邮件：nazhenkun@him.cas.cn
个人简历
那振坤博士于2014年6月获得新加坡国立大学化学专业博士学位，随后在耶鲁大学从事博士后研究工作。致力于开发新型化学生物学技术鉴定非经典翻译蛋白的功能的研究，并取得了一系列创新性的科研成果，近年来发表SCI论文21篇，其中以第一/共同第一作者身份在包括Nat.Biotechnol., Mol. Cell, J. Am. Chem. Soc., Cell Res., Angew. Chem. Int. Ed.等国际著名期刊上发表论文9篇。
研究方向
肿瘤代谢与非经典翻译蛋白的生物功能
承担科研项目情况
中科院百人“B"类人才，浙江省优秀青年人才项目
代表论著
1. Dai, X.#; Park, J.#; Du, Y.#; Na, Z.#; Chu, Z.; Liao, C.; Clark, P.; Slavoff, S.A.; Chen, S.* “Massively parallel knock-in engineering of human T cells”. Nat. Biotechnol. 2023, 41, 1239-1255. # Contributed equally to this work.
2. Na, Z.; Dai, X.; Zheng, S.; Bryant, C.; Loh, K. H.; Baserga, S.; Chen, S.; Slavoff, S. A.* “Mapping subcellular localizations of unannotated microproteins with MicroID”, Mol. Cell, 2022, 82, 2900-2911.
3. Na, Z.; Luo, Y.; Cui, D; Khitun, A.; Smelyansky, S.; J. P. Loria; Slavoff, S. A.* “Phosphorylation of the NBDY microprotein promotes dissociation of biomolecular condensation”, J. Am. Chem. Soc., 2021, 143(32), 12675-12687.
4. Na, Z.; Luo, Y.; Khitun, A.; Schofield, J. A.; Smelyansky, S.; Muthukumar, S.; Valkov, E.; Simon, M. D.; Slavoff, S. A.* “The NBDY microprotein determines the specificity of cellular RNA decapping”, Biochemistry, 2020, 59,4131-4132.
5. Luo, Y. #; Na, Z. #; Slavoff, S. A.* “P-bodies: composition, properties and functions”, Biochemistry, 2018, 57(17): 2424-2431. # Contributed equally to this work.
6. Na, Z.; Yeo, S.; Bharath, S. R.; Wang, C.; Song, H.* “Structural Basis for Blocking PD-1 Mediated Immune Response by Therapeutic Antibody Pembrolizumab”, Cell Res., 2017, 27, 147-150.
7. Na, Z.; Peng, B.; Ng, S.; Pan, S.; Lee, J.; Shen, H.; Yao, S. Q. * “A Small Molecule Protein-Protein Interaction Inhibitor of PARP1 that targets Its BRCT domain ”, Angew. Chem. Intl. Ed., 2015, 54, 2515-2519.
8. Na, Z.; Pan, S.; Uttamchandani, M.; Yao, S. Q.* “Discovery of Cell-Permeable Inhibitors that Target the BRCT domain of BRCA1 Protein by using Small Molecule Microarray”, Angew. Chem. Intl. Ed., 2014, 53, 8421-8426.
(Highlighted by Dr. Russell Johnson et al. in Nat. Chem., 2014, 6, 657.)
9. Na, Z.; Li, L.; Yao, S. Q.* “Microarray-Guided Discovery of Two-Photon(2-P) Small Molecule Probes For Live-Cell Imaging of Cysteinyl Cathepsins Activities”, Chem. Commun., 2012, 48, 7304-7306
