中国科学院杭州医学所研究员，核酸适体筛选中心副主任，浙江省卫健委创新人才项目培养对象。主要研究方向为核酸适体与分子诊疗学研究：1）新一代核酸适体筛选方法学研究；2）核酸适体数字化细胞图谱与识别机理；3）生物标志物发现与检测新方法研究；4）核酸适体分子诊疗试剂和产品开发。在Adv. Sci.，JACS，Anal. Chem.等学术期刊发表学术论文60余篇，其中第一（含共同）或通讯作者论文20余篇；申请国内专利20余项（授权12项），其中PCT专利2项，美国专利1项； 2013与2017年度分别荣获中国分析测试协会科学技术奖一等奖、二等奖；主持或参与国家级、省部级项目10余项。目前聚焦于新一代细胞核酸适体筛选新技术和前沿应用研究。    

核酸适体与分子诊疗    

1. 基于核酸适体的受体蛋白磷酸化/去磷酸化精准调控与动态监测研究 （22274139），国家自然科学基金委面上项目，2023.01-2026.12，54万，主持
2. 用于细胞图谱的重要 CD 分子核酸适体的筛选及机理研究( YXD24B0401),浙江省自然科学基金，2024.01-2026.12， 100万，主持
3. 2022年度浙江省卫生创新人才项目，省卫健委，2023.1-2027.12，40万，主持
4. 结直肠癌标志物发现和多参数检测新技术，（WKJ-ZJ-2424），“国家卫生健康委科学研究基金-浙江省卫生健康重大科技计划”重大项目，2024.1-2026.12，30万，主持 
5. 病原感染的特异多重识别与信息转换（2293031），重大项目，2023.1-2027.12，468万，参与
6. 核酸适体结构功能研究，浙江省“尖兵”“领雁”研发攻关计划项目（2023SDYXS0002），2023.1-2025.12，900万，参与
    

1) Wu, X.*;  Liu, Y.;  Zhang, D.;  Yu, J.;  Zhang, M.;  Feng, S.;  Zhang, L.;  Fu, T.;  Tan, Y.;  Bing, T.*; Tan, W.*, Efficient Strategy to Discover DNA Aptamers Against Low Abundance Cell Surface Proteins in Scarce Samples. J Am Chem Soc 2024, 146 (39), 26667-26675.
2) Zhang, X.#;  Zhang, N.#;  Sun, H.;  Li, D.;  Long, Z.;  Sheng, J.;  Zu, S.;  Bing, T.*; Shangguan, D.*, A Bispecific Chimeric Aptamer Design Platform Based on c-MET Aptamer with a Replaceable Redundant Region. Chembiochem : a European journal of chemical biology 2024, e202400501.
3) Zhang, D.#;  Liu, Y.#;  Huang, H.;  Fu, T.;  Bing, T.*;  Wu, X.*; Tan, W.*, Streamlining RNA Aptamer Selection via Unique Molecular Identifiers and High-Throughput Sequencing. Analytical Chemistry 2024. doi.org/10.1021/acs.analchem.4c02984
4）Lv, J.#; Zhen, X.#; Li, D.#; Liao, G.; Long, Z.; Zhang, N.; Liu, X.; Bing, T.*; Shangguan, D., Generation of an Aptamer Targeting Receptor-Type Tyrosine-Protein Phosphatase F. Analytical Chemistry 2023, 95 (2), 1228–1233
5) Sun, Y.; Zhang, Z.; Bing, T.*; Liu, J.; Li, W.; Liu, X.; Zhang, N.; Shu, Y.*; Wang, J.; Shangguan, D.*, Aptamer-Based Cell Nucleus Imaging via Expansion Microscopy. Analytical Chemistry 2022, 94 (15), 6044-6049.
6) Shen, L.#; Jia, K.#; Bing, T.*; Zhang, Z.; Zhen, X.; Liu, X.; Zhang, N.; Shangguan, D.*, Detection of circulating tumor-related materials by aptamer capturing and endogenous enzyme-signal amplification. Analytical Chemistry 2020, 92 (7), 5370−5378.
7) Wang, J.; Bing, T*.; Zhang, N.; Liu, X.; Shangguan, D.*, FnCas12a/crRNA assisted dumbbell-PCR detection of IsomiRs with terminal and inner sequence variants. Chem Commun 2020, 56, 10038 - 10041.
8) Shen, L. Y.; Bing, T.*; Zhang, N.; Wang, L. L.; Wang, J. Y.; Liu, X. J.; Shangguan, D. H.*, A Nucleus-Targeting DNA Aptamer for Dead Cell Indication. ACS Sensors 2019, 4 (6), 1612-1618.
9) Wang, J. Y.; Bing, T.*; Zhang, N.; Shen, L. Y.; He, J. Q.; Liu, X. J.; Wang, L. L.; Shangguan, D. H.*, The Mechanism of the Selective Antiproliferation Effect of Guanine-Based Biomolecules and Its Compensation. ACS Chem Biol 2019, 14 (6), 1164-1173.
10) Shen, L. Y.; Bing, T.*; Liu, X. J.; Wang, J. Y.; Wang, L. L.; Zhang, N.; Shangguan, D. H.*, Flow Cytometric Bead Sandwich Assay Based on a Split Aptamer. ACS Appl Mater Inter 2018, 10 (3), 2312-2318.
11) Bing, T.#; Shen, L.#; Wang, J.; Wang, L.; Liu, X.; Zhang, N.; Xiao, X.; Shangguan, D.*, Aptameric Probe Specifically Binding Protein Heterodimer Rather Than Monomers. Advanced Science. 2019, 6 (11), 1900143.
12) Wang, L.#; Bing, T.#; Liu, Y.; Zhang, N.; Shen, L.; Liu, X.; Wang, J.; Shangguan, D.*, Imaging of Neurite Network with an Anti-L1CAM Aptamer Generated by Neurite-SELEX. J. Am. Chem. Soc. 2018, 140, 18066-18073.
13) Bing, T.#; Wang, J.#; Shen, L.; Liu, X.; Shangguan, D.*, Prion Protein Targeted by a Prostate Cancer Cell Binding Aptamer, a Potential Tumor Marker? ACS Appl. Bio Mater. 2020, 3 (5), 2658-2665.