郭沛

郭沛


  • 电子邮件:guopei@him.cas.cn

个人简历

2012年本科毕业于华中师范大学化学学院,2016年博士毕业于香港中文大学化学系,2016-2019年于香港中文大学化学系从事博士后研究,2019-2022年于华南理工大学生物科学与工程学院任副研究员,2022年7月加入中国科学院杭州医学研究所。研究方向为核酸化学、疾病相关核酸结构与功能、生物核磁共振波谱。以第一或通讯作者身份在PNAS、Nat. Commun.、J. Am. Chem. Soc.、Nucleic Acids Res.等期刊发表论文20余篇。主持国家自然科学基金面上和青年项目,浙江省和广东省自然科学基金项目等。

研究方向

核酸结构生物学、智能核酸分子设计、生物磁共振波谱

承担科研项目情况

国家自然科学基金面上项目,脊髓小脑共济失调36型相关DNA和RNA六核苷酸重复序列的结构与功能研究,2024.01-2027.12,主持。 浙江省自然科学基金重大项目,神经退行性疾病相关核酸结构与功能研究,2025.01-2027.12,主持。 国家自然科学基金青年项目,CAG三核苷酸RNA重复序列溶液结构的核磁共振研究,2021.01-2023.12,主持。 国家自然科学基金委专项项目,核酸适体药物序列-结构协同设计的预训练基座模型开发与论证,2024.01-2026.12,参与。 浙江省“尖兵”“领雁”重点研发计划项目,核酸适体结构功能研究,2023.01-2025.12,参与。

代表论著

1. He, A., Wan, L., Zhang, Y., Yan, Z., Guo, P.*, Han, D.* and Tan, W.* (2024) Structure- based investigation of a DNA aptamer targeting PTK7 reveals an intricate 3D fold guiding functional optimization. Proceedings of the National Academy of Sciences of the United States of America, 121, e2404060121 2. Yang, L.#, Tang, Q.#, Zhang, M., Tian, Y., Chen, X., Xu, R., Ma, Q., Guo, P.*, Zhang, C.* and Han, D.* (2024) A spatially localized DNA linear classifier for cancer diagnosis. Nature Communications, 15, 4583. 3. Wang, Y.#, Wang, J.Y.#, Yan, Z.Z., Hou, J.N., Wan, L.Q., Yang, Y.Q., Liu, Y., Yi, J., Guo, P.* and Han, D.* (2024) Structural investigation of pathogenic RFC1 AAGGG pentanucleotide repeats reveals a role of G-quadruplex in dysregulated gene expression in CANVAS. Nucleic Acids Research, 52, 2698-2710. 4. Wan, L.#, He, A.#, Li, J., Guo, P.* and Han, D.* (2024) High-resolution NMR structures of intrastrand hairpins formed by CTG trinucleotide repeats. ACS Chemical Neuroscience, 15, 868-876. 5. Li, J.#, Wan, L.#, Wang, Y., Chen, Y., Lee, H.K., Lam, S.L.* and Guo, P.* (2023) Solution nuclear magnetic resonance structures of ATTTT and ATTTC pentanucleotide repeats associated with SCA37 and FAMEs. ACS Chemical Neuroscience, 14, 289-299. 6. Yi, J.#, Wan, L.#, Liu, Y., Lam, S.L., Chan, H.Y.E.*, Han, D.* and Guo, P.* (2022) NMR solution structures of d(GGCCTG)n repeats associated with spinocerebellar ataxia type 36. International Journal of Biological Macromolecules, 201, 607-615. 7. Guo, P.* and Han, D.* (2022) Targeting pathogenic DNA and RNA repeats: A conceptual therapeutic way for repeat expansion diseases. Chemistry – A European Journal, 28, e202201749. 8. Guo, P.* and Lam, S.L.* (2020) Minidumbbell structures formed by ATTCT pentanucleotide repeats in spinocerebellar ataxia type 10. Nucleic Acids Research, 48, 7557-7568. 9. Guo, P. and Lam, S.L.* (2017) An extraordinarily stable DNA minidumbbell. The Journal of Physical Chemistry Letters, 8, 3478-3481. 10. Guo, P. and Lam, S.L.* (2016) The competing mini-dumbbell mechanism: new insights into CCTG repeat expansion. Signal Transduction and Targeted Therapy, 1, 16028. 11. Guo, P. and Lam, S.L.* (2016) Minidumbbell: a new form of native DNA structure. Journal of the American Chemical Society, 138, 12534-12540.

获奖及荣誉

第27届国际生物体系磁共振会议青年研究员奖