本人长期从事肿瘤、传染性疾病、免疫治疗和核酸疫苗等方向的研究，致力于设计与开发新型环形mRNA疫苗、免疫新疗法、基因编辑及核酸纳米探针。 博士后工作经历： (1) 2021-08 至 2022-05, Virginia Commonwealth University (2) 2019-05 至 2021-08, 中山大学附属第一医院 (3) 2019-01 至 2019-05, Virginia Commonwealth University (4) 2016-07 至 2019-01, 中国科学院化学研究所 科研与学术工作经历： (1) 2022-12 至今, 中国科学院杭州医学研究所, 医学所, 助理研究员 (2) 2022-05 至 2022-12, Virginia Commonwealth University, Department of Pharmacy, 助理研究员

核酸疫苗

浙江省自然科学基金项目重大项目

1.Yu Zhang, Xiang Liu, Tingting Shen, Qiyan Wang, Shurong Zhou, Suling Yang, Shimiao Liao, Ting Su, Lei Mei, Bei Zhang, Khoa Huynh, Linying Xie, Youzhong Guo, Chunqing Guo, Katarzyna M Tyc, Xufeng Qu, Xiang-Yang Wang, Jinze Liu, Guizhi Zhu*. Small circular mRNA vaccines for cancer immunotherapy. Nature Biomedical Engineering (Accepted) (中科院一区，IF=26.8) 2.You Xu, Xiang Liu, Shurong Zhou, Suling Yang, Khoa Huynh, Linying Xie, Youzhong Guo, Chunqing Guo, Katarzyna M Tyc, Xiang-Yang Wang, Jinze Liu, Yu Zhang*, Guizhi Zhu*. Pulmonary delivery of small circular mRNA vaccines for protection from influenza infection. Nature Communications (under review) (中科院一区，IF=16.6) 3.Yu Zhang, Tingting Shen, Shurong Zhou, Weinan Wang, Shuibin Lin*, Guizhi Zhu*, pH- Responsive STING-Activating DNA Nanovaccines for Cancer Immunotherapy. Advacned Therapeutics, 2020, 3(9): 2000083. (JCR二区，IF=3.7) 4.Yu Zhang, Shuibin Lin*, Xiang‐Yang Wang*, Guizhi Zhu*, Nanovaccines for cancer immunotherapy. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2019, 11(5): e1559. (中科院二区，IF=6.9) 5.Tingting Shen, Yu Zhang, Shurong Zhou, Shuibin Lin, Xiao-Bing Zhang*, Guizhi Zhu*, Nucleic acid immunotherapeutics for cancer, ACS Applied Bio Materials, 2020, 3(5): 2838-2849 (共同第一作者) (JCR二区，IF=4.6) 6.Ting Su, Yu Zhang, Kristoffer Valerie, Xiang-Yang Wang, Shuibin Lin*, Guizhi Zhu*, STING activation in cancer immunotherapy, Theranostics, 2019, 9(25): 7759-7771 (共同第一作者) (中科院一区，IF=12.4) 7.Yu Zhang, Ting-Ting Shen, Hao-Li Zhang, Alexander M. Kirillov, Hui-Juan Cai, Jiang Wu, Wei-Sheng Liu, Yu Tang*, A multifunctional nanocomposite for luminescence resonance energy transfer-guided synergistic monitoring and therapy under single near infrared light. Chemical Communications, 2016, 52(27): 4880-4883. (中科院二区，IF=4.3) 8.Yu Zhang, Ting-Ting Shen, Alexander M. Kirillov, Wei-Sheng Liu, Yu Tang*, NIR light/H2O2-triggered nanocomposites for a highly efficient and selective synergistic photodynamic and photothermal therapy against hypoxic tumor cells. Chemical Communications, 2016, 52: 7939. (中科院二区，IF=4.3) 9.Yu Zhang, Tingting Shen, Xia Deng, Yufei Ma, Lina Wang, Yong Peng, Jiang Wu, Zhijun Zhang, Weisheng Liu and Yu Tang*, Design of a versatile nanocomposite for ‘seeing’ drug release and action behavior. J. Mater. Chem. B, 2015, 3: 8449. (中科院二区，IF=6.1)

1.Zhu G, Zhang Y. Small circular mRNA therapeutics and vaccines, and the methods of use thereof. 2022, WO 2022/173730 (授权) 2.Zhu G, Zhang Y. Immunostimulatory cyclic di-nucleotide delivery system compositions and methods of use thereof. 2022, WO/2022/221536 (授权)