2022年博士毕业于美国罗格斯大学药理学专业，2022-2024年在美国新泽西肿瘤研究所和ProtTech Inc.公司先后进行博士后和高级研究员工作。主要从事肠道炎症和肿瘤的发病机制研究，在Cell Stem Cell, Blood, Nature Metabolism, The Journal of Clinical Investigation, Nature Communications等国际学术期刊上发表近20篇学术论文。2024年5月入所，致力于肠道疾病和肿瘤的靶向药物研发，聚焦核酸药物的基础与转化研究。

1. 肠道细胞与肠道疾病发生发展的关系；2. 免疫逃逸和代谢重塑对结直肠癌发生发展的影响；3. 药物的作用机制及临床运用。

1. 医学所启动经费，2024QD05，2024/05-2029/05，100万元，项目负责人，在研； 2. 美国新泽西肿瘤研究委员会博士后基金，Targeting intestinal epithelium-immune cell crosstalk in colorectal cancer，COCR24PDF006，2023/09-2025/08，140万元，项目负责人，在研。

Jianming Wang, Chun-Yuan Chang, Xue Yang, Fan Zhou, Juan Liu, Jill Bargonetti, Lanjing Zhang, Ping Xie, Zhaohui Feng, Wenwei Hu. p53 suppresses MHC class II presentation by intestinal epithelium to protect against radiation-induced gastrointestinal syndrome. Nat commun. 2024 Jan 2;15(1):137. [IF: 16.6] Jianming Wang, Chun-Yuan Chang, Xue Yang, Fan Zhou, Juan Liu, Sining Zhu, Xue-Zhong Yu, Chen Liu, Timothy E. O’Sullivan, Ping Xie, Zhaohui Feng, Wenwei Hu. Leukemia inhibitory factor protects against graft-versus-host disease while preserving graft-versus-leukemia activity. Blood. 2022 Nov 10;140(19):2076-2090. [IF: 20.3] Jianming Wang, Chun-Yuan Chang, Xue Yang, Fan Zhou, Juan Liu, Zhaohui Feng, Wenwei Hu. Leukemia inhibitory factor, a double-edged sword with therapeutic implications in human diseases. Mol Ther. 2023 Feb 1;31(2):331-343. [IF: 12.4] Chun-Yuan Chang*, Jianming Wang*, Yuhan Zhao*, Juan Liu, Xue Yang, Xuetian Yue, Huaying Wang, Fan Zhou, Juan Inclan Rico, John Ponessa, Ping Xie, Lanjing Zhang, Mark Siracusa, Zhaohui Feng, Wenwei Hu. Tumor suppressor p53 regulates intestinal type 2 immunity. Nat commun. 2021 Jun 7;12(1):3371. [IF: 16.6] (*: 共同一作) Xuetian Yue*, Jianming Wang*, Chun-Yuan Chang, Juan Liu, Xue Yang, Fan Zhou, Xia Qiu, Vrushank Bhatt, Jessie Yanxiang Guo, Xiaoyang Su, Lanjing Zhang, Zhaohui Feng, Wenwei Hu. Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis. Cell Death Dis. 2022 Apr 19;13(4):370. [IF: 9] (*: 共同一作) Huaying Wang*, Jianming Wang*, Yuhan Zhao, Xiao Zhang, Juan Liu, Cen Zhang, Bruce Haffty, Lanjing Zhang, Nan Gao, Zhaohui Feng, and Wenwei Hu. LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. Cell Death Dis. 2020 Jul 27;11(7):588. [IF: 9] (*: 共同一作) Xue Yang, Jianming Wang, Chun-Yuan Chang, Fan Zhou, Juan Liu, Huiting Xu, Maria Ibrahim, Maria Gomez , Grace L. Guo, Hao Liu, Wei-Xing Zong, Fredric E Wondisford, Xiaoyang Su, Eileen White, Zhaohui Feng, Wenwei Hu. Leukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice. Nat commun. 2024 Jan 20;15(1):627. [IF: 16.6] Lei Chen, Xia Qiu, Abigail Dupre, Oscar Pellon-Cardenas, Xiaojiao Fan, Xiaoting Xu, Prateeksha Rout, Katherine D. Walton, Joseph Burclaff, Ruolan Zhang, Wenxin Fang, Rachel Ofer, Alexandra Logerfo, Kiranmayi Vemuri, Sheila Bandyopadhyay, Jianming Wang, Gaetan Barbet, Yan Wang, Nan Gao, Ansu O. Perekatt, Wenwei Hu, Scott T. Magness, Jason R. Spence, Michael P. Verzi. TGFB1 induces fetal reprogramming and enhances intestinal regeneration. Cell Stem Cell. 2023 Nov 2;30(11):1520-1537.e8. [IF: 23.9] Juan Liu, Cen Zhang, Tianliang Zhang, Chun-Yuan Chang, Jianming Wang, Ludvinna Bazile, Lanjing Zhang, Bruce G Haffty, Wenwei Hu, Zhaohui Feng. Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer. Nat Metab. 2022 Dec;4(12):1830-1846. [IF: 20.8] Juan Liu, Cen Zhang, Dandan Xu, Tianliang Zhang, Chun-Yuan Chang, Jianming Wang, Jie Liu, Lanjing Zhang, Bruce G. Haffty, Wei-Xing Zong, Wenwei Hu, Zhaohui Feng. The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain-of-function in cancer. J Clin Invest. 2023 Mar 15;133(6):e164354. [IF: 15.9] Vrushank Bhatt, Taijin Lan, Wenping Wang, Jerry Kong, Eduardo Cararo Lopes, Jianming Wang, Khoosheh Khayati, Akash Raju, Michael Rangel, Enrique Lopez, Zhixian Sherrie Hu, Xuefei Luo, Xiaoyang Su, Jyoti Malhotra, Wenwei Hu, Sharon R Pine, Eileen White, Jessie Yanxiang Guo. Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors. Cell Death Dis. 2023 Jan 26;14(1):61. [IF: 9] Xiaohui Sun, Bin Liu, Sitong Liu, David J H Wu, Jianming Wang, Yi Qian, Ding Ye, Yingying Mao. Sleep disturbance and psychiatric disorders: a bidirectional Mendelian randomisation study. Epidemiol Psychiatr Sci. 2022 Apr 25;31:e26. [IF: 8.1] Cen Zhang, Juan Liu, Jianming Wang, Wenwei Hu, Zhaohui Feng. The emerging role of leukemia inhibitory factor in cancer and therapy. Pharmacol Ther. 2021 May;221:107754. [IF: 13.4] Cen Zhang, Juan Liu, Jianming Wang, Tianliang Zhang, Dandan Xu, Wenwei Hu, Zhaohui Feng. The Interplay between Tumor Suppressor p53 and Hypoxia Signaling Pathways in Cancer. Front Cell Dev Biol. 2021 Feb 18;9:648808. [IF: 6.081] Xuetian Yue, Fangnan Wu, Jianming Wang, Kaitlin Kim, Bindu Santhamma, Kalarickal V. Dileep, Kam Y.J. Zhang, Gulzar Ahmed, Zhaohui Feng, Klaus Nickisch, and Wenwei Hu. EC330, a small molecule compound, is a potential novel inhibitor of leukemia inhibitory factor signaling. J Mol Cell Biol. 2020 Jul 3;12(6):477-480. [IF: 5.5] Juan Liu, Cen Zhang, Jianming Wang, Wenwei Hu, Zhaohui Feng. The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway. Int J Mol Sci. 2020 Nov 9;21(21):8387. [IF: 6.208] Yuhan Zhao, Lihua Wu, Xuetian Yue, Cen Zhang, Jianming Wang, Jun Li, Xiaohui Sun, Yiming Zhu, Zhaohui Feng, and Wenwei Hu. A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models. Elife. 2018 Mar 20;7:e34701. [IF: 7.7] Xiaohui Sun, Yiping Tian, Jianming Wang, Zeyuan Sun, Yimin Zhu. Genome-wide analysis reveals the association between alternative splicing and DNA methylation across human solid tumors. BMC Med Genomics. 2020 Jan 6;13(1):4. [IF: 2.7]

专利：Lif therapy for inducing intestinal epithelial cell regeneration. Worldwide Patent, WO2020176752A1, September 3, 2020, Wenwei Hu, Zhaohui Feng, Huaying Wang and Jianming Wang. Lif therapy for inducing intestinal epithelial cell regeneration. United States Patent, US20220096602A1, March 31, 2022, Wenwei Hu, Zhaohui Feng, Huaying Wang and Jianming Wang.