吕德官，研究员，博士生导师，博士后合作导师，国家级海外青年人才计划入选者。主要从事胶质母细胞瘤病理和转化应用研究，通过探究胶质母细胞瘤（⼲）细胞生物学功能确定适合药理学靶向的核⼼调控途径和发现新的治疗⽅法。相关研究成果发表在Cell Metabolism, Molecular Cell, Cancer Discovery, Nature Communications等国际高水平杂志， H指数 26，i10指数34，总 引⽤⼤ 于 2300次， 担任 eLife、Cancer Letters、BBA-reviews on Cancer等 20余本杂 志 的 专 业 审 稿 ⼈ ， 同 时 担 任 Frontiers in Oncology 、 Frontiers in Immunology、Frontiers in Genetics 等杂志编辑。AACR（美国癌症研究协会） 和 Society for Neuro-Oncology 的成员。

肿瘤干细胞命运调控与靶向治疗、肿瘤代谢微环境与免疫重塑、多组学与生物信息分析、衰老与癌症

国家级海外青年人才项目

1. Deguan Lv, Deobrat Dixit, Andrea F. Cruz, Leo J.Y. Kim,  Likun Duan, Xin Xu, Qiulian Wu, Cuiqing Zhong, Chenfei Lu, Zachary C. Gersey, Ryan C. Gimple, Qi Xie, Kailin Yang, Xiaojing Liu, Xiaoguang Fang, Xujia Wu, Reilly L. Kidwell, Xiuxing Wang, Shideng Bao, Housheng H. He, Jason W. Locasale, Sameer Agnihotri, Jeremy N. Rich. Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2. Cell Metabolism. 2024;36(11):2419-2436. 

2. Deguan Lv, Cuiqing Zhong, Deobrat Dixit, Kailin Yang, Qiulian Wu, Bhaskar Godugu, Briana C Prager, Guofeng 

Zhao, Xiuxing Wang, Qi Xie, Shideng Bao, Chuan He, Dieter Henrik Heiland, Michael G Rosenfeld, Jeremy N Rich. EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma. Molecular Cell. 2023;83(23):4334-4351.

3. Deguan Lv, Kailin Yang, Jeremy N. Rich. Growth factor receptor signaling induces mitophagy through epitranscriptomic regulation. Autophagy. 2023, 19(3):1034-1035. 

4. Deguan Lv, Ryan C. Gimple, Cuiqing Zhong, Qiulian Wu, Kailin Yang, Briana C. Prager, Bhaskar Godugu, Zhixin Qiu, Linjie Zhao, Guoxin Zhang, Deobrat Dixit, Derrick Lee, Jia Z. Shen, Xiqing Li, Qi Xie, Xiuxing Wang, Sameer Agnihotri, Jeremy N. Rich PDGF Signaling inhibits Mitophagy in Glioblastoma Stem Cells Through N 6-Methyladenosine. Developmental Cell, 2022; S1534-5807(22)00349-5. 

5. Deguan Lv, Xuling Luo, Zhe Chen, Jiaqi Liu, Meiqing Liu, Yao Li, Shifang Huang, Mingzhu Tang, Li Yang, Liqun Lu, Jinyong Jiang, Qionglin Zhou, Feng Xie, Cuiqing Zhong, Lanfang Li, Linxi Chen. Apelin/APJ signaling activates autophagy to promote human lung adenocarcinoma cell migration. Life Sciences. 2021; 281:119763. 

6. Deguan Lv, Yanxin Li, Weiwei Zhang, Angel A Alvarez, Lina Song, Jianming Tang, Wei-Qiang Gao, Bo Hu, Shi-Yuan Cheng, Haizhong Feng. TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma. Nature Communications. 2017;8(1):1454. 

7. Deguan Lv, Feng Jia, Yanli Hou, Youzhou Sang, Angel A Alvarez, Weiwei Zhang, Wei-Qiang Gao, Bo Hu, Shi-Yuan Cheng, Jianwei Ge, Yanxin Li, Haizhong Feng. Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding. Cancer Research. 2017; 77(22):6190-6201. doi: 10.1158/0008-5472.CAN-17-1388.