王雅俊
- 电子邮件：wangyajun@him.cas.cn
个人简历
王雅俊，现任中国科学院杭州医学研究所生物治疗与组学中心研究员，博士生导师。获中国科学院 “B类”（2024）、浙江省“海外高层次人才计划”青年项目（2023）资助。主持国家自然科学基金青年项目（22107083，2021-2024），面上项目（22577134，2026-2029）。致力于化学生物学与合成生物学交叉领域的研究，核心目标是系统探索核酸的化学与生物学特性，开发核酸分子的大规模、精准生物合成与修饰平台，并推动其在药物研发与生物技术中的应用。近五年，以第一作者和通讯作者（含共同）于Nature Chemistry、Advanced Materials、Journal of the American Chemical Society、Nature Communications、Nucleic Acids Research、Chemical Science等期刊发表研究论文。
研究方向
致力于化学生物学与合成生物学交叉领域的研究，核心目标是系统探索核酸的化学与生物学特性，开发核酸分子的大规模、精准生物合成与修饰平台，并推动其在药物研发与生物技术中的应用。具体研究内容聚焦于以下三个方面：（1）核酸的基础化学生物学研究，涵盖含有非天然碱基和糖环结构的功能性核酸、小核酸、mRNA等；（2）通过蛋白工程化与人工智能辅助的蛋白设计与进化，开发核酸分子的大规模、精准生物合成与修饰方法，（3）开发基于 DNA、RNA 与 XNA 等多种核酸的功能分子、分子工具与治疗药物，为细胞命运与生物体系调控及疾病诊断和治疗提供新的策略。
承担科研项目情况
获中国科学院 “BR计划 B 类”（2024）、浙江省“海外高层次人才计划”青年项目（2023）资助。主持国家自然科学基金青年项目（22107083，2021-2024），面上项目（22577134，2026-2029）。
代表论著
1. Zhang,Z.;Qian,H.;Xu,R.;Duan,Q.;Wang,Y.;Fu,T.;Wu,X.;Sha,C.;Wu,Q.;Wang,Yajun*; Tan,W*. Chemical Evolution of Double Covalent Aptamers for Sustained Protein Degradation and Improved Cytotoxicity in NK-Cell-Mediated Tumor Therapy. J. Am. Chem. Soc. 2025. https://doi.org/10.1021/jacs.5c11823.
2. Gao,M.;Liu,Y.;Zhao,L.;Chen,J.;Wan,W.;Yuan,Z.;Li,L.;Huang,Y.;Wang,Yajun*;Zheng,Y*. Cell Surface-Tethered Nucleic Acid Therapeutics Program Robust and Tumor-Responsive Enhancement of Adoptive Cell Therapy. Adv. Mater. 2025,e2419969.
3. Liu,Y.;Zhang,S.;Zhang,M.;Liu,X.;Wu,Y.;Wu,Q.;Chaput,J. C.;Wang,Yajun*. Chemical Evolution of ASO-like DNAzymes for Effective and Extended Gene Silencing in Cells. Nucleic Acids Res. 2025,53 (5),gkaf144.
4. Liu,Y.;Wang,J.;Wu,Y.;Wang,Yajun*. Advancing the Enzymatic Toolkit for 2′-Fluoro Arabino Nucleic Acid (FANA) Manipulation: Phosphorylation,Ligation,Replication,and Templating RNA Transcription. Chem. Sci. 2024,15 (31),12534–12542. 5. Yingyu Liu,Yajun Wang*. Making Nucleic Acid Monomers. Nat. Chem.,2022,14,725-727.
6. Yajun Wang,John Chaput*. Advancing XNAzymes as Nucleic Acid Therapeutics. Handbook of Chemical Biology of Nucleic Acids,2022,DOI: https://doi.org/10.1007/978-981-16-1313-5.
7. Yajun Wang,Xiaolin Liu,Mouhamad Shehabat,Nicholas Chim,John,Chaput. Transliteration of synthetic genetic enzymes. Nucleic acids Res. 2021,20,11438-11446.
8. Yajun Wang#,Kim Nguyen#,Robert C. Spitale,John C. Chaput*. A Biologically Stable DNAzyme that Efficiently Silences Gene Expression in Cells. Nat. Chem.,2021,4,319-326 (# co-first author).
9. Kim Nguyen#,Yajun Wang#,Whitney England,John C. Chaput*,Robert C. Spitale*. Allele-Specific RNA Knockdown with a Biologically Stable and Catalytically Efficient XNAzyme. J. Am. Chem. Soc., 2021,12,4519-4523 (# co-first author).
10. Hui Mei,Yajun Wang,Eric J. Yik,John C. Chaput. Synthesis and polymerase recognition of a pyrrolocytidine TNA triphosphate. Biopolymers,2021,112,e23388.
11. Yajun Wang,Alexander Vorperian,Mouhamad Shehabat,John C. Chaput. Evaluating the Catalytic Potential of a General RNA-Cleaving FANA Enzyme. ChemBioChem,2020,21,1001-1006.
12. Yajun Wang,Arlene Ngor,Ali Nikoomanzar,John Chaput. Evolution of a general RNA-Cleaving FANA enzyme. Nat. Commun. 2018,9,5067-5076.
13. Yajun Wang,Erkai Liu,Curtis Lam,David Perrin. A densely modified M2+-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover. Chem. Sci.,2018,9,1813-1821.
14. Hui Mei,Jen-yu Liao,Randi M. Jimenez,Yajun Wang,Saikat Bala,Cailen McCloskey,Christopher Switze,and John C. Chaput. Synthesis and evolution of a threose nucleic acid aptamer bearing 7-deaza-7-substituted guanosine residues. J. Am. Chem. Soc.,2018,140,17,5706-5713.
15. Yajun Wang,Nicole Ng,Erkai Liu,Curtis Lam,David Perrin. Systematic study of constraints imposed by modified nucleoside triphosphates with protein-like side chains for use in in vitro selection. Org. Biomol. Chem.,2017,15,610-618.
16. Hui Mei,Changhua Shi,Randi Jimenez,Yajun Wang,Kardouh,Miramar,John,Chaput. Synthesis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue. Nucleic Acid Res., 2017,10,5629-5638.
