研究员，博士生导师，国家级海外青年人才计划入选者。2017年于暨南大学获得生物化学与分子生物学博士学位。同年赴美国Mayo Clinic开展博士后研究，2023年起任Mayo Clinic药理学系助理教授。期间曾获Edward C. Kendall Fellowship in Biochemistry Award，并主持两项Mayo Clinic早期职业生涯发展基金项目。2025年起加入中国科学院杭州医学研究所担任课题组长。研究聚焦于DNA损伤应答调控网络及其在肿瘤发生发展、放化疗耐受的分子机制。近年来以第一作者或通讯作者（含共同）在Nature、Molecular Cell（3篇）、Nature communications（2篇）等国际主流杂志发表9篇学术论文，其中1篇入选ESI统计的高被引论文。

课题组运用经典的生物化学与分子生物学方法，结合先进的单分子实验、超分辨率显微成像及蛋白质组学等技术，构建以DNA损伤应答通路为切入点的研究体系，聚焦DNA代谢核心事件（DNA损伤、重组与DNA复制），系统解析其在肿瘤发生发展及放化疗耐受中的分子机制，旨在为肿瘤精准治疗提供新的理论依据与潜在靶点。研究方向包括但不限于：

1. DNA代谢与肿瘤治疗耐受机制；

2. DNA复制与转录机器的调控机制；

3. 基于多组学与交叉学科方法研究DNA损伤修复通路与肿瘤治疗。

国家自然科学基金优秀青年科学基金项目（海外）

1. Kloeber JA, Chen B, Sun G, King CS, Wang Z, Wang L, Wu Z, Zhu S, Zhao F, Qin H, Ouyang Y, Xiao H, Tu X, Lu J, Jiang Y, Luo K, Yin P, Wu X, Mutter RW, Huang J, Lou Z. KCTD10 is a sensor for co-directional transcription-replication conflicts. Nature. 2025 Oct 8. doi:10.1038/s41586-025-09585-9. (Co-corresponding author)

2. Huang J, Wu C, Kloeber JA, Gao H, Gao M, Zhu Q, Chang Y, Zhao F, Guo G, Luo K, Dai H, Liu S, Huang Q, Kim W, Zhou Q, Zhu S, Wu Z, Tu X, Yin P, Deng M, Wang L, Yuan J, Lou Z. SLFN5-mediated chromatin dynamics sculpts higher-order DNA repair topology. Mol Cell. 2023 Apr 6;83(7):1043-1060.e10. (First author)

3. Huang J, Zhou Q, Gao M, Nowsheen S, Zhao F, Kim W, Zhu Q, Kojima Y, Yin P, Zhang Y, Guo G, Tu X, Deng M, Luo K, Qin B, Machida Y, Lou Z. Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging. Mol Cell. 2020 Sep 3;79(5):824-835.e5. (First author)

4. Huang JZ, Chen M, Chen, Gao XC, Zhu S, Huang H, Hu M, Zhu H, Yan GR. A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth. Mol Cell. 2017 Oct 5;68(1):171-184.e6. (First author)

5. Zhou Q, Huang J, Zhang C, Zhao F, Kim W, Tu X, Zhang Y, Nowsheen S, Zhu Q, Deng M, Chen Y, Qin B, Luo K, Liu B, Lou Z, Mutter RW, Yuan J. The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair. Nat Commun. 2020 May 26;11(1):2639. (Co-first author)

6. Zhu Q, Huang J, Huang H, Li H, Yi P, Kloeber JA, Yuan J, Chen Y, Deng M, Luo K, Gao M, Guo G, Tu X, Yin P, Zhang Y, Su J, Chen J, Lou Z. RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination. Nat Commun. 2021 Nov 17; 12 (1):6653. (Co-first author)

7. Gao M, Qi Z, Deng M, Huang H, Xu Z, Guo G, Jing J, Huang X, Xu M, Kloeber JA, Liu S, Huang J, Lou Z, Han J. The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1. Oncogene. 2022 Aug;41(33):4018-4027. (Co-corresponding author)

8. Gao M, Qi Z, Feng W, Huang H, Xu Z, Dong Z, Xu M, Han J, Kloeber JA, Huang J, Lou Z, Liu S, m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis, J Biol Chem. 2022 Jan 5;101563. (Co-corresponding author)

9. Huang JZ, Chen M, Zeng M, Xu SH, Zou FY, Chen D, Yan GR. Down-regulation of TRPS1 stimulates epithelial-mesenchymal transition and metastasis through repression of FOXA1. J Pathol. 2016 Jun;239(2):186-96. (First author)