魏永
- 电子邮件：weiyong@him.cas.cn
个人简历
中国科学院BR计划获得者，浙江省领军人才。课题组长期致力于“不可成药”蛋白质相互作用的靶向干预，重点开发核酸适体抑制剂及其在疾病治疗中的应用。在核酸适体理性设计、作用机制解析及转化应用等方面取得系列成果，相关研究以第一或通讯作者发表在Nature Structural & Molecular Biology、Cell Chemical Biology、Nature Communications、Advanced Science, Nucleic Acids Research等期刊，为竞争性核酸适体干预“不可成药”蛋白质互作提供新工具和新思路。课题组先后获得国家自然科学基金、科技部重点研发计划、浙江省自然科学基金等多项资金支持。
课题组主页：30-https://www.x-mol.com/groups/WeiLab-HIM
代表论著
1. Liyan Fei, Yichun Pan, Jie Zhai, Tongqing Li, Yuxin Zhou, Sheyu Zhang, Juan Wei, Qian Hu, Xueying Liu, Lu Guo, Weizhu Wu, Yong Wei,* Qin Wu,* Weihong Tan*. PTf-SRiApt Targeting SCAF4-POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple-Negative Breast Cancer. Advanced Science. 2025
2. Tongqing Li#, Xueying Liu#, Haifeng Qian, Sheyu Zhan, Yu Hou, Yuchao Zhang, Guoyan Luo, Xun Zhu, Yanxin Tao, Mengyang Fan, Hong Wang, Chulin Sha, Ailan Lin, Jingjing Qin, Kedan Gu, Weichang Chen, Ting Fu, Yajun Wang, Yong Wei*, Qin Wu*, Weihong Tan*. Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions. Nature Communications. 2024
3. Ke-Jing Zhang#, Juan Wei#, She-Yu Zhang#, Yi-Shuai Ji, Wen-Jun Chen, Felipe E. Ciamponi, Wei-Chang Chen, Meng-Xi Li, Ting Fu, Katlin B. Massirer, Mathieu Lupien, Yong Wei*, Cheryl. H. Arrowsmith*, Qin Wu*, Wei-Hong Tan*.A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer. Cell chemical Biology. 2024
4. Hang Yin#, Xuzichao Li#, Xiaoshen Wang, Chendi Zhang, Jiaqi Gao, Guimei Yu, Qiuqiu He, Jie Yang, Xiang Liu, Yong Wei*, Zhuang Li*, Heng Zhang*. Insights into the modulation of bacterial NADase activity by phage proteins. Nature Communications. 2024
5. Xinna Zhang, Yu Hou, Weichang Chen, Ting Fu*, Yong Wei*, Weihong Tan*. Inhibitory DNA aptamer tools against SOCS3-gp130 interactions. ACS Applied Materials & Interfaces. 2024
6. Yong Wei #, Cornelia Redel#, Alexandra Ahlner #, Alexander Lemak , Isak Johansson-Åkhe, Scott Houliston, Tristan M G Kenney, Aaliya Tamachi , Vivian Morad, Shili Duan, David W Andrews, Björn Wallner, Maria Sunnerhagen*, Cheryl H Arrowsmith*, Linda Z Penn* .
The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase. Nucleic Acids Research. 2022
7. Yong Wei #, Diana Resetca # , Zhe Li , Isak Johansson-Åkhe , Alexandra Ahlner , Sara Helander , Amelie Wallenhammar , Vivian Morad , Brian Raught , Björn Wallner, Tetsuro Kokubo, Yufeng Tong , Linda Z Penn*, Maria Sunnerhagen*. Multiple direct interactions of TBP with the MYC oncoprotein. Nature structure molecular biology. 2019
