罗华程，研究员，博士生导师，国家级高层次人才项目入选者，浙江省海外高层次人才计划(创新长期项目)入选者。先后在美国佛罗里达大学和美国宾夕法尼亚州立大学从事科研工作，曾获得美国白血病基金会(LRF)和美国国家癌症研究所(NCI)的科研资助。目前，课题组专注于恶性肿瘤发生发展中的分子调控网络解析，并探索功能核酸在肿瘤治疗中的新策略，主要研究领域：1). 揭示功能核酸靶向m6A甲基化酶在恶性肿瘤发生发展中的调控机制及其在肿瘤治疗中的应用探索；2). 阐明长链非编码RNA调控染色质三维结构在造血系统和白血病发生中的分子机理；3). 胰腺癌早期诊断的生物标志物挖掘及胰腺炎癌转化的分子机制解析。研究团队已经在肿瘤基因组学、染色质三维空间结构组学、RNA表观遗传学和表观组学等领域获得了突破性进展。相关研究成果以第一或通讯作者发表在Cancer Cell (封面文章), Blood (封面文章), Molecular Cell (封面文章), Leukemia, Science Advances, Nature Communications, Oncogene, Advanced Science, Cell Reports等国际权威期刊。

恶性肿瘤发生发展的调控机制及靶向治疗研究

国家级高层次人才项目；主持2项国家自然科学基金-面上项目；主持浙江省自然科学基金-重大项目；中国科学院杭州医学所人才启动金；以及参与中国科学院B类先导专项等科研项目。

1.Huacheng Luo, Ganqian Zhu, Jianfeng Xu, Qian Lai, Bowen Yan, Ying Guo, Tsz Kan Fung, Bernd B. Zeisig, Ya Cui, Jie Zha, Christopher Cogle, Fei Wang, Bing Xu, Feng-Chun Yang, Wei Li, Chi Wai Eric So, Yi Qiu, Mingjiang Xu, and Suming Huang. HOTTIP lncRNA promotes hematopoietic stem cell self-renewal leading to AML-like disease in mice. Cancer Cell.(2019),36(6):645-659.(影响因子: 50.3)(封面文章).

2.Huacheng Luo, Fei Wang, Jie Zha, Haoli Li, Bowen Yan, Qinghua Du, Fengchun Yang, Amin Sobh, Christopher Vulpe, Leylah Drusbosky, Christopher Cogle , Iouri Chepelev , Bing Xu , Stephen D. Nimer , Jonathan Licht, Yi Qiu,Baoan Chen, Mingjiang Xu, and Suming Huang. CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia. Blood. (2018), 132(8):837-848.(影响因子: 25.476) (封面文章).

3. Huacheng Luo, Ganqian Zhu, Melanie Eshelman, Xiaoyan Ma, Qian Lai, Nicholas Cesari, Shi Chen, Christopher Cogle, Ruben Mesa, Sinisa Dovat, Chi Wai Eric So, Feng-Chun Yang, Yi Qiu, Mingjiang Xu, and Suming Huang. HOTTIP dependent R-loop formation regulates CTCF boundary and TAD integrity in acute myeloid leukemia. Molecular Cell.(2022),82(4):833–851.(影响因子: 19.328) (封面文章).

4. Qian Lai*, Karina Hamamoto*, Huacheng Luo*, Julia Lesperance, Jie Zha, Yi Qiu, Olga Guryanova, Suming Huang, and Bing Xu. NPM1 mutation reprograms leukemic transcription network via reshaping TAD topology. Leukemia. (2023),37(8):1732-1736. (影响因子: 12.883).

5.Ajeet Singh*, Huacheng Luo*,#(通讯作者), Meghana Matur, Melanie Eshelman, Karina Hamamoto, Arati Sharma, Julia Lesperance, Suming Huang. A coordinated function of lncRNA HOTTIP and miRNA-196b underpinning leukemogenesis by targeting Fas signaling. Oncogene. (2022),41(5):718-731. (影响因子: 9.867). 

6.Ganqian Zhu*, Huacheng Luo* (共一), Yang Feng, Olga A. Guryanova, Jianfeng Xu, Shi Chen, Qian Lai, Arati Sharma, Bing Xu, Zhigang Zhao, Ru Feng, Hongyu Ni, David Claxton, Ying Guo, Ruben A. Mesa, Yi Qiu, Feng-Chun Yang, Wei Li, Stephen D. Nimer, Suming Huang and Mingjiang Xu. HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia. Nature Communications.(2021),12(1):1956. (影响因子: 17.694).

7.Huacheng Luo, Qin Yu, Yang Liu, Ming Tang, Mingwei Liang, Dingpeng Zhang, Tsan Sam Xiao, Lizi Wu, Ming Tan, Yijun Ruan, Jörg Bungert, Jianrong Lu. LATS kinase-mediated CTCF phosphorylation and selective loss of genomic binding. Science Advances.(2020),6(8):eaaw4651. (影响因子:14.957). 

8.Yiju Wei*, Huacheng Luo* (共一), Patricia P. Yee, Lijun Zhang, Zhijun Liu, Haiyan Zheng, Lei Zhang, Benjamin Anderson, Suming Huang and Wei Li. Paraspeckle Protein NONO Promotes TAZ Phase Separation in the Nucleus to Drive the Oncogenic Transcriptional Program. Advanced Science.(2021), 8(24):e2102653. (影响因子: 17.521).

9.Huacheng Luo, Anitha K Shenoy, Xuehui Li, Yue Jin, Lihua Jin, Qingsong Cai, Ming Tang, David Reisman, Lizi Wu, Yi Qiu, Yali Dou, Robert Casero, Yang Liu, Jianrong Lu. MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition. Cell Reports.(2016),15(12), 2665–2678. (影响因子: 9.995).

2021年获得美国白血病基金会的科研奖励；

2019年获得美国血液学年会Achievement Award；

2017年获得美国血液学年会Achievement Award.