2021-现在，中国科学院杭州医学研究所，研究员

课题组聚焦肿瘤精准医学研究，构建"技术开发-机制解析-临床转化"研究体系，通过开发高性能分子探针，融合发展单细胞测序、空间蛋白组学等前沿技术，开发多组学数据智能解析模型，系统绘制肿瘤发生发展的时空动态图谱，开发靶向治疗新策略及伴随诊断生物标志物实现个性化精准治疗。

中国科学院战略先导专项（首席科学家），国家自然科学基金面上（主持），国家自然科学基金青年（主持），国家自然科学基金优秀青年（海外）（主持），浙江省尖兵领雁重点研发 （主持），浙江省杰出青年项目（主持，结题优秀），IT-BT 科技部重点研发课题 （主持）

1. Liyan Fei,Yichun Pan,Jie Zhai,Tongqing Li,Yuxin Zhou,Sheyu Zhang,Juan Wei,Qian Hu,Xueying Liu,Lu Guo,Weizhu Wu,Yong Wei,* Qin Wu,* Weihong Tan*. PTf-SRiApt Targeting SCAF4-POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple-Negative Breast Cancer. Advanced Science. 2025

2. Xiaoqiu Wu,Xinrui Lin,Xiangqi Ma,Huidong Huang,Dengwei Zhang,Yuqing Liu,Rui Cheng,Jia Song,Lifei Zhang,Yamin Tan,Ruizi Peng,Tao Bing*,Qin Wu*,Weihong Tan*. High-Throughput Multiplexed Quantification of Molecules by Aptamer Sequencing (Apt-seq) in Single Cells. JACS,2025

3.Kejign Zhang#,Juanwei#,Sheyu Zhang#,....,Cheryl Arrowsmith*,Qin Wu*,Weihong Tan*,A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer. Cell Chemical Biology,2024

4.Tongqing Li#,Xueying Liu#,....,Yong Wei*,Qin Wu*,Weihong Tan*,Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions. Nature Communications,2024

5.Qiao Duan#,Haoran Jia#,….,Qin Wu*,Weihong Tan*,Multivalent Aptamer-Based Lysosome-Targeting Chimeras (LYTACs) Platform for Mono- or Dual-Targeted Proteins Degradation on Cell Surface. Advanced Science,2308924,2024

6.Sheyu Zhang#,Lu Guo#,...,Xiaojia Wang*,Qin Wu*,Type I protein arginine methyltransferase inhibition primes anti‐programmed cell death protein 1 immunotherapy in triple negative breast cancer. Cancer,1–9,2023;

7.Qin Wu*,David Y Nie...,Cheryl Arrowsmith*,PRMT inhibition induces a viral mimicry response in triple-negative breast cancer. Nature Chemical Biology  18(8):821-830,2022

8.Qin Wu,Cheryl Arrowsmith*,Dalia Barsyte-Lovejoy,Therapeutic targeting of arginine methylation: from enigmatic functions to clinical applications. Nature Reviews Drug Discovery  20(7):509-530,2021

9.Qin Wu#,Wail ba-alawi#,Mathieu Lupien,Cheryl H. Arrowsmith*,GLUT1 inhibition blocks growth of RB1-positive Triple Negative Breast Cancer.  Nature Communications. 21;11(1):4205,2020

10.Qin Wu,David Heidenreich,….,Cheryl H. Arrowsmith*,Oleg Fedorov,Panagis Filippakopoulos& Stefan Knapp*;A chemical toolbox for the study of bromodomains and epigenetic signaling. Nature Communications. 10,1915,2019.

11.Qin Wu,Truttmann MC,Ploegh HL,Hepta-mutant S. anreus sortase A (SrtA7m) as a tool for in vivo protein labeling in Caenorhabditis elegans. ACS Chem. Bio. 2017 Mar 17;12(3):664-673. doi: 10.1021 

12.Qin Wu#,Qinqin Cheng#,Siming Yuan,Junchao Qian,Kai Zhong,Yinfeng Qian,Yangzhong Liu,A Cell- Penetrating Protein Designed for Bimodal Fluorescence and Magnetic Resonance Imaging. Chem. Sci.,2015,DOI: 10.1039/C5SC01925G.

13.Qin Wu,Zengqiang Gao,Yong Wei,Guolin Ma,Yuchuan Zheng,Yuhui Dong,Yangzhong Liu. Conserved Residues that Modulate Protein trans-Splicing of Npu DnaE Split Intein. Biochemical Journal. 2014,461(2),247. 

14.Guolin Ma,Qin Wu,(Co-first author),Xuelei Wu,Fabio Arnesano,Giovanni Natile,Einar Sletten,Yangzhong Liu. The Reaction of a Platinated Methionine Motif of CTR1 with Cysteine and Histidine Is Dependent upon the Type of Precursor Platinum Complex,J. Inorg. Biochem. 2015 Dec;153:239-46

15.Abdellah Allali-Hassani,….,Qin Wu,Benjamin Nicholson6,Masoud Vedadi,Discovery of a chemical probe for PRDM9. Nat Commun. 2019 Dec 17;10(1):5759 

16.Yupeng He,….,Steven Kennedy,Qin Wu,….,  William N Pappano. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nature Chem. Bio. 2017,10.1038. 

17.Truttmann MC,Qin Wu,Stiegeler S,Duarte JN,Ingram J,Ploegh HL.HypE-specific nanobodies as tools to modulate HypE-mediated target AMPylation. J. Biol. Chem.,2015 Apr 3 290(14). 

中国科学院上海分院杰出青年

中国科学院上海分院三八红旗手先进个人