1.2023.01-2026-12 国家自然科学基金（面上） “设计、构建X-射线辐射闪烁体发光系统诱导“炎性-程序性细胞死亡”及其在抗肿瘤治疗中的应用研究” 32271485 主持 54万 

2.2023.01-2025.12 浙江省自然科学基金（重大）“利用光遗传学工具激活PI3K-AKT-mTOR信号通路研究中枢神经系统的髓鞘再生机制” YXD23H0302 主持 100万 3.2023-12~2028-11 国家重点研发计划 罕见病模型构建及基因治疗研究 2023YFC3403400 课题骨干 76万 

4.2024.12– 2029.11 国家重点研发计划 响应型核酸元件与基因线路的设计与构建 2024YFA0916700 课题骨干 100万  

5.2022.07-2026.06 浙江省卫健委 浙江省卫生 高层次人才 （创新人才） - 主持 40万

6.2021-10~2022-09 中国科学院杭州医学研究所 利用光遗传学建立细胞坏死性凋亡介导的抗肿瘤免疫体内模型 QTJC20210013-B 主持 5万  7.2021.07-2026.07 中国科学院杭州医学研究所 启动经费 2021QD11 主持 200万

通讯作者

• Lian H, Huang Z, Chen R, Zhou Y and Jing J. Optogenetic Control of Non-Apoptotic Cell Death. Advanced Science. 2021, 2100424. https://doi.org/10.1002/advs.202100424 (IF=15.8) 

• Chen R, Zhang N, Zhou Y, and Jing J. Optical Sensors and Actuators for Probing Proximity -Dependent Biotinylation in Living Cells. Frontiers in cellular Neuroscience. 2022 Feb 16. https://doi.org/10.3389/fncel.2022.801644

• Lin G, Shi W, Zhang N, Lee YT, Wang Y, and Jing J. Proteomic mapping and optogenetic manipulation f membrane contact sites. Biochemical Journal. 2022 Sep 16.https://doi.org/10.1042/BCJ20220382

• Nguyen N, Zhou Y, Jing J. Optogenetic approaches in calcium signaling Optogenetic approaches to control Ca2+-modulated physiological processes. Current Opinion in Physiology. 2020 Oct; 17: 187–196. Published online 2020 Aug 16. https://doi.org/10.1016/j.cophys.2020.08.004

• Zirui Zhuang, Yuxin Meng, Yu Xue, Yan Wang, Xiangdong Cheng and Ji Jing*. Adaptation of STIM1 structure-function relationships for optogenetic control of calcium signaling. Journal of Biological Chemistry. 2024. Available online 8 August 2024, 107636. https://doi.org/10.1016/j.jbc.2024.107636. 

• Yangchan Hu，Yuxin Meng，Zirui Zhuang，Yuancong Li，Junjun Nan, Ning Xu, Zu Ye，Ji Jing*. Prospects for PARG inhibitors in cancer therapy. Journal of Molecular Cell Biology. 2024. Published online 12 December 2024. https://doi.org/10.1093/jmcb/mjae050

• Can Hu, Jingli Xu, Yanqiang Zhang, Ruolan Zhang, Siwei Pan, Jiahui Chen, Yan Wang, Qianyu Zhao, Yuqi Wang, Weiwei Zhu, Mengxuan Cao, Shengjie Zhang, Dan Zu, Zhiyuan Xu*, Ji Jing*, Xiangdong Cheng*. Inhibition of Glutathione Peroxidase 4 Suppresses Gastric Cancer Peritoneal Metastasis via Regulation of RCC2 Homeostasis. Redox Biology. 2025. 

著  作

• Zhang N, Jing J.An optogenetic toolbox for remote control of programmed cell death. Book: Opsin-free Optogenetics: Technology and Applications. 2022. Imprint CRC Press. eBook ISBN 9781003280750

第一作者

• Jing J*, He L*, Sun A*, Quintana A*, Ding Y*, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y, Zhou Y. Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx. Nature Cell Biology. 2015 Aug 31. doi: 10.1038/ncb3234. (亮点文章in Nature Cell Biology “News and Views”) * Equal contribution.

• Jing J, Liu G, Huang Y, and Zhou Y. A molecular toolbox for interrogation of membrane contact sites.  Journal of Phsiology. 2019. https://doi.org/10.1113/JP277761

• Jing J, Zhou Y, and Wang Y. Dimming the donor to brighten up FRET-based biosensors Cell Calcium. 2021 Nov. 99:102474. https://doi.org/10.1016/j.ceca.2021.102474. 

共同第一作者

• Zhang J*, Tripathi DN*, Jing J*, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nature Cell Biology 2015 Sep 7. doi: 10.1038/ncb3230. * Equal contribution. (亮点文章 in Nature Cell Biology “News and Views”)

• Zhang Z*, Jing J*, Ye Y, Chen Z, Jing Y, Li S, Hong W, Ruan H, Liu Y, Hu Q, Huang Y, Li W, Lin C, Diao L, Zhou Y and Han L. Characterization of the dual functional effects of heat shock proteins (HSPs) in cancer hallmarks to aid development of HSP inhibitors. Genome Med 12, 101 (2020). https://doi.org/10.1186/s13073-020-00795-6.* equal contribution. 

• He L*, Jing J*, Tan P. Ma G, Huang Y and Zhou Y. Optical control of membrane tethering and interorganellar communications at nanoscales. Chemical Science. 2017. doi: 10.1039/C7SC01115F *Equal contribution (封面文章)

• Chen R*, Jing J*, Siwko S, Huang Y, Zhou Y. Intelligent cell-based therapies for cancer and autoimmune disorders. Current Opinion in Biotechnology. 2020 Dec; 66:207-216. https://doi.org/10.1016/j.copbio.2020.08.012. Epub 2020 Sep 18. * equal contribution.

• Jing Li*, Ji Jing*, Yang Bai, Zhen Li, Roumei Xing, Binhe Tan, Xueyun Ma, Wen-Wei Qiu, Changsheng Du, Bing Du, Fan Yang, Jie Tang, Stefan Siwko, Mingyao Liu, Huaqing Chen and Jian Luo. SH479, a Betulinic Acid Derivative, Ameliorates Experimental Autoimmune Encephalomyelitis by Regulating the T Helper 17/Regulatory T Cell Balance. Mol Pharmacol. 2017 May;91(5):464-474. doi: 10.1124/mol.116.107136. Epub 2017 Feb 17.

• Jia Y*, Jing J*, Yang Bai, Zhen Li, Lande Liu, Jian Luo, Mingyao Liu, Huaqing Chen. Amelioration of Experimental Autoimmune Encephalomyelitis by Plumbagin through Down-Regulation of JAK-STAT and NF-kB Signaling Pathways. PLoS One. 2011; 6(10): e27006. Epub 2011 Oct 31. https://doi.org/10.1371/journal.pone.0027006. *Equal contribution

其  他

• Nhung Thi Nguyen, Kai Huang, Hongxiang Zeng, Ji Jing, Rui Wang, Shaohai Fang, Joyce Chen, Xin Liu, Zixian Huang, M James You, Anjana Rao, Yun Huang, Gang Han, Yubin Zhou. Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety. Nat Nanotechnol. 2021 Dec. 16(12):1424-1434.

doi: 10.1038/s41565-021-00982-5.

• Tripathi DN, Zhang J, Jing J, Dere R, Walker CL. A new role for ATM in selective autophagy of peroxisomes (pexophagy). Autophagy. 2016;12(4):711-2. doi: 10.1080/15548627.2015.1123375.

• Yang Z, Yan H, Dai W, Jing J, Yang Y, Mahajan S, Zhou Y, Li W, Melians E, Shih C, Fitzpatrick J, and Faccio R. Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1. Journal of Autoimmunity. 2019. (PMID: 31018906)

• Autoimmune Encephalomyelitis by Regulating the T Helper 17/Regulatory T Cell Balance. Molecular Pharmacology.  May 2017, 91 (5) 464-474; DOI: https://doi.org/10.1124/mol.116.107136

• Nguyen NT, Ma G, Lin E, D'Souza B, Jing J, He L, Huang Y, Zhou Y. CRAC channel-based optogenetics. Cell Calcium. 2018 Nov;75:79-88. doi: 10.1016/j.ceca.2018.08.007. Epub 2018 Sep 3. Review. PubMed PMID: 30199756.

• Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, Lee M, Fang S, Jing J, Johnson G, Sun D, Cao WM, Dashwood R, Han L, Dong WG, Zhou Y, Wei-Guo Dong, and Huang Y. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene. 2018 (PMID: 30390073)

• Anoop Singh Chauhan, Xiaoguang Liu, Ji Jing, Hymine Lee, Raj Kumar Yadav, Jindou Liu, Yubin Zhou, Boyi Gan. STIM2 interacts with AMPK and regulates calcium-induced AMPK activation. FASEB Journal. 2018 (PMID: 30335546)

• Liu Z, Li H, He L, Yu X, Tian C, Tan P, Li C, Jing J, Tian Y, Du L, Huang Y, Han L, Li M, and Zhou Y. Discovery of small molecule inhibitors of the HSP90-calcineurin-NFAT pathway against glioblastoma. Cell Chemical Biology. 2018,26:1-14.(PMID: 30639261)

• Ma G, He L, Jing J, Tan P, Huang Y, Zhou Y. Engineered Cross-Linking to Study the Pore Architecture of the CRAC Channel. Methods Mol Biol. 2018;1843:147-166. (PMID: 30203285)

• Tan P, Ye Y, He L, Xie J, Jing J, Ma G, Pan H, Han L, Han W, and Zhou Y. TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. PLOS Biology. 2018,16(11):e3000051. (PMID: 30408026)

• He L*, Zhang Y*, Ma G*, Tan P*, Li Z, Zang S, Wu X, Jing J, Fang S, Zhou L, Wang Y, Huang Y, Hogan P, Han G & Zhou Y. Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. eLIFE. 2015,pi:e10024 (*equal contribution; doi: 10.7554/elife.10024; PMID: 26646180)

• Ma G*, Wei M*, He L*, Liu C*, Wu B, Zhang SL, Jing J, Liang X, Senes A, Tan P, Li S, Sun A, Bi Y, Zhong L, Si H, Shen Y, Li M, Lee MS, Zhou W, Wang J, Wang Y, Zhou Y. Inside-out Ca2+ signaling prompted by STIM1 conformational switch. Nature Communications. 2015,6:7826. DOI: 10.1038/ncomms8826. (PMID: 26184105) *Equal contribution

• Quintana A, Rajanikanth V, Farber-Katz S, Gudlur A, Chen Z, Jing J, Zhou Y, Rao A and Hogan PG. TMEM110 regulates the maintenance and remodelling of mammalian ER-plasma membrane junctions competent for STIM-ORAI signalling. PNAS. 2015, 112(51):E7083-92. (doi: 10.1073/pnas.1521924112; PMID: 26644574)

• Yi-Xing Huang, Han-Yi He, Ken Chen, Hai-Dong Liu, Dan Zu, Chen Liang, Qi-Mei Bao, Yang-Chan Hu, Guo-Xia Liu, Yu-Ke Zhong, Chun-Kai Zhang, Ming-Cong Deng, Yan-Hua He, Ji Jing, Yin Shi, Sheng-Feng Xu, Yao-Shu Teng, Zu Ye, Xiang-Dong Cheng. Prognostic impact and reasons for variability by tumor location in gastric cancer. World J Gastroenterol. 2024 Nov 28;30(44):4709-4724. doi: 10.3748/wjg.v30.i44.4709.

专 利

• 荆吉，孟宇新，胡杨婵，庄子睿，程向东，叶足。Sp1作为FBXO44启动子区域的转录因子的应用。专利权人：中国科学院杭州医学研究所 浙江工业大学。申请号： 202411288193.5

• 叶足，黄懿行，程向东，荆吉，周卫，滕尧树，汪丁祎。羟喜树碱在制备诱发细胞焦亡的制剂中的应用。专利权人：中国科学院杭州医学研究所。专利号：ZL 2024 1 0899315.8

• 叶足，程向东，陈肯，邓明聪，钟雨珂，张淳凯，诗音，荆吉。滕尧树胃腺癌预后相关分子标记物组合、胃腺癌预后评估模型。专利权人：中国科学院杭州医学研究所。专利号：ZL 2024 1 1262128.5

奖励：

• 2023.11 浙江省科学技术进步一等奖（4/13）

• 2019.8   The Postdoctoral Scholar Travel Award, TAMU

• 2018.4   Graduate Research Excellence Award, College of Medicine, TAMU (每年一个人获奖)

• 2017.9   American Society for Cell Biology (ASCB) Immigrant Travel Award

• 2017.8   The best poster award, the second Organellar channels and transporters, Gordon Research Conference.