1. Signaling Molecule from Intratumor Bacteria Promotes Trastuzumab Resistance in Breast Cancer Cells. Gege Qina, Xiying Shao, Xiaolong Liu, Jiachao Xu, Xiaojia Wang, Wenxi Wang, Lu Gao, Yuxin Liang, Lina Xie, Dan Su, Hongwei Yang,Wei Zhou*, and Xiaohong Fang,* Proc Natl Acad Sci USA. 2025, 122(2), e2421710122。

2. Ultrasensitive quantification of microRNA copy number in individual extracellular vesicles using DNA tetrahedron-based single-molecule imaging", Liu, Weifeng; Yang, Hongwei; Liu, Xiaolong; Cai, Heqi; Bao, Yuting; Jiang, Yifei; Zhou, Wei; Yuan, Jinghe; Zhang, Zhen; Fang, Xiaohong, Anal.Chem. 2025，97, 4233-4240.

3. Self-stacked small molecules for ultrasensitive, substrate-free Raman imaging in vivo.  Shuai Gao , Yongming Zhang, Kai Cui , Sihang Zhang , Yuanyuan Qiu, Yunhui Liao , Haoze Wang, Sheng Yu , Liyang Ma, Hongzhuan Chen, Minbiao Ji, Xiaohong Fang*, Wei Lu* , Zeyu Xiao*,Nature biotechnology 2024 doi: 10.1038/s41587-024-02342-9

4. Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions. Molecular Cell. 2024. 84, 1-18

5. Ultrasensitive Point-of-Care Detection of Protein Markers Using an Aptamer-CRISPR/Cas12a-Regulated Liquid Crystal Sensor (ALICS). Lubin Qi; Jie Liu; Songlin Liu; Yang Liu; Yating Xiao; Zhen Zhang; Wei Zhou; Yifei Jiang*; Xiaohong Fang*. Anal. Chem. 2024, 96(2), 866–875.

6. Ultra-sensitive Detection of Cancer Biomarkers using Photonic-crystal-enhanced Single-molecule Imaging,: Liu, Songlin; Ma, Bochen; Qi, Liqing; Ping, Jiantao; Che, YuDong; Zhang, YiMin; Su, Meng; Song, Yanlin; Qi, Lubin* ; Jiang, Yifei*; Fang, Xiaohong*, Anal. Chem. 2024, 96(33), 13719-13726.

7. Inhibition of LRPPRC/CDK6 Positive Feedback Loop Overcomes CDK4/6 Inhibitor Resistance in Lung Cancer,  Wei Zhou,Wenxi Wang, Yuxin Liang, Ruibing Jiang, Fensheng Qiu,  Juan Ni,Yang Liu, Lina Wang, Maowei Ni,  Weiwei Li,  Qiqi Xue,  Lubin Qi,  Michael J. Donovan, Weijia Huang, Chenhuan Yu,Yue Zhao,  Jiong Li,  Ting Fu, Jianguo Feng, Weihong Tan, * and Xiaohong Fang*， Nature Communications, 2023, 14(1):4212.

8. Reprogramming Hypoxic Tumor-associated Macrophages by Nanoglycoclusters for Boosted Cancer Immunotherapy, Yong-Dan Zhao, Hong-Wei An, Muhetaerjiang Mamuti, Xiang-Zhong Zeng, Rui Zheng, Jia Yang, Wei Zhou, Yuxin Liang, Gege Qin, Da-Yong Hou, Xiaolong Liu, Hao Wang*, Yuliang Zhao*, Xiaohong Fang* , Advanced Materials 2023， 35(24):e2211332

9. Mitochondrial protease targeting chimeras for mitochondrial matrix protein degradation. Dachi Wang, Wenxi Wang, Le Fang, Lubin Qi, Zhou Wei*, Xiaohong Fang* . J. Am. Chem. Soc., 2023, 145(23), 12861-12869

10. Hyperbranched Polymer Dots with Strong Absorption and High Fluorescence Quantum Yield for In Vivo NIR-II Imaging. Le Fang, Rui Ai, Wenxi Wang, Lei Tan, Chanyuan Li, Dachi Wang, Ruibin Jiang, Fensheng Qiu, Liqing Qi, Jian Yang, Wei Zhou, Tao Zhu, Weihong Tan, Yifei Jiang,* and Xiaohong Fang*, Nano Lett. 2023, 23(18), 8734.

11. Surface-Engineered Gold Nanoclusters for Stimulated Emission Depletion and Correlated Light and Electron Microscopy Imaging. Yang H, Wu Y, Ruan H, Guo F, Liang Y, Qin G, Liu X, Zhang Z, Yuan J*, Fang X*. Anal Chem. 2022 Feb 22;94(7):3056-3064

12. Deep learning in single-molecule imaging and analysis: recent advances and prospects. Liu X, Jiang Y, Cui Y, Yuan J*, Fang X*. Chem Sci. 2022 Sep 22;13(41):11964-11980.

13. G-Quadruplex-Induced Liquid-Liquid Phase Separation in Biomimetic Protocells. Liu X, Xiong Y, Zhang C, Lai R, Liu H, Peng R, Fu T, Liu Q*, Fang X*, Mann S*, Tan W*. , J Am Chem Soc. 2021，143(29):11036-11043.

14. Single-Molecule Imaging of Protein Interactions and Dynamics, Fang Luo, Gege Qin, Tie Xia, Xiaohong Fang*, Annu. Rev. Anal. Chem. 2020, 13, 337-361.

15. Photorelease of Pyridines Using the Metal-free Photoremovable Protecting Group, Xiaojun Tang, Yayun Wu, Rong Zhao, Xiaolong Kou, Zaizai Dong, Wei Zhou, Zhen Zhang, Weihong Tan, Xiaohong Fang*, Angew. Chem. Int. Ed. 2020, 59, 18386-18389

16. Fluorescent Polymer Dot-Based Multicolor Stimulated Emission Depletion Nanoscopy with a Single Laser Beam Pair for Cellular Tracking,Yayun Wu, Hefei Ruan, Zaizai Dong, Rong Zhao, Jianqiang Yu, Xiaojun Tang, Xiaolong Kou, Xing Zhang, Manchen Wu, Fang Luo, Jinghe Yuan*, and Xiaohong Fang*, Anal. Chem. 2020, 92, 17, 12088–12096

17. Jiachao Xu, Gege Qin, Fang Luo, Lina Wang, Rong Zhao, Nan Li, Jinghe Yuan*, Xiaohong Fang*, Automated Stoichiometry Analysis of Single-Molecule Fluorescence Imaging Traces via Deep Learning, J. Am. Chem. Soc. 2019,141, 6976-6985

18. Proteasome Independent Protein Knockdown by Small-Molecule Inhibitor for the Undruggable Lung Adenocarcinoma, Wei Zhou, Guogui Sun, Zhen Zhang, Libo Zhao, Li Xu, Hongyu Yuan, Shumu Li, Zaizai Dong, Yongmei Song*, Xiaohong Fang*,        J. Am. Chem. Soc. 2019,141, 18492-18499

19. Hypoxia-activated PEGylated aptamer/antibody for cancer imaging with improved specificity, Fang Zhou, Ting Fu, Qin Huang, Hailan Kuai, Liuting Mo, Honglin Liu, Qianqian Wang, Yongbo Peng, Dongmei Han, Zilong Zhao*, Xiaohong Fang*, Weihong Tan*, J. Am. Chem. Soc. 2019,141, 18421-18427

20. Molecular Engineering-Based Aptamer-Drug Conjugates with Accurate Tunability of Drug Ratios for Drug Combination Targeted Cancer Therapy , Fang Zhou, Peng Wang, Yongbo Peng, Pengge Zhang, Qin Huang, Weidi Sun, Nongyue He,Ting Fu, Zilong Zhao,* Xiaohong Fang*, Weihong Tan*, Angew. Chem. Int. Ed. 2019, 58, 11661 –11665

21. Analysis of Diffusivity Change from Single-molecule Trajectories on Living Cells, Rong Zhao, Jinghe Yuan, Nan Li, Yahong Sun, Tie Xia, and Xiaohong Fang*, Anal. Chem. 2019, 91, 13390-13397