金程
- 电子邮件：jincheng@him.cas.cn
个人简历
2018年毕业于湖南大学，获理学博士学位；2019年-2022年在牛津大学化学系从事博士后研究；2023年入职中国科学院杭州医学研究所，任副研究员；2024年2月，晋升为研究员，博士生导师。
研究方向
核酸分子基元、创新核酸药物
承担科研项目情况
承担国家自然科学基金优秀青年科学基金项目（海外）、青年基金，浙江省自然科学基金重点项目等科研项目
代表论著
(1) Engineering enzyme‐cleavable oligonucleotides by automated solid‐phase incorporation of cathepsin B sensitive dipeptide linkers. Cheng Jin; Afaf H. EI‐Sagheer; Siqi Li; Katherine A. Vallis; Weihong Tan; Tom Brown*, Angew. Chem. Int. Ed. 2022, 61, e202114016
(2) Modular and automated synthesis of oligonucleotide-small molecule conjugates for cathepsin B mediated traceless release of payloads. Cheng Jin*; Siqi Li; Katherine A. Vallis; Afaf H. El-Sagheer; Tom Brown*, RSC Chem. Biol., 2024, 5, 738-744
(3) Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression. Cheng Jin; Jiaxuan He; Jianmei Zou; Wenjing Xuan; Ting Fu; Ruowen Wang; Weihong Tan*, Nat. Commun. 2019, 10, 2704
(4) Floxuridine homomeric oligonucleotides “hitchhike” with albumin in situ for cancer chemotherapy. Cheng Jin#; Hui Zhang#; Jianmei Zou; Yan Liu; Lin Zhang; Fengjie Li; Ruowen Wang; Wenjing Xuan; Mao Ye*; Weihong Tan*, Angew. Chem. Int. Ed. 2018, 57, 29, 8994-8997
(5) Conformational conversion enhances cellular uptake of F base double-strand-conjugated oligonucleotides. Huarong Bai#; Cheng Jin#; Jianmei Zou; Ruowen Wang; Ting Fu*; Weihong Tan*, Anal. Chem. 2020, 15, 92, 10375-10380.
(6) Engineering stability-tunable DNA micelles using photocontrollable dissociation of an intermolecular G-quadruplex. Cheng Jin; Xiaojing Liu; Huarong Bai; Ruowen Wang; Jie Tan; Xuehui Peng; Weihong Tan*, ACS Nano, 12, 11, 12087-12093
(7) Fluorinated DNA micelles: synthesis and properties. Jianmei Zou#; Cheng Jin#; Ruowen Wang; Hailan Kuai; Lili Zhang; Xiaobing Zhang; Juan Li; Liping Qiu*; Weihong Tan*, Anal. Chem. 2018, 11, 90, 6843-6850
(8) Fluorinated molecular beacons as functional DNA nanomolecules for cellular imaging. Cheng Jin#; Ting Fu#; Ruowen Wang*; Hui Liu; Jianmei Zou; Zilong Zhao; Mao Ye; Xiaobing Zhang; Weihong Tan*, Chem. Sci. 2017, 8, 10, 7082-7086
(9) Artificial base zT as functional “element” for constructing photore-sponsive DNA nanomolecules. Ruowen Wang#; Cheng Jin#; Xiaoyan Zhu; Liyi Zhou; Wenjing Xuan; Yuan Liu; Qiaoling Liu; Weihong Tan*, J. Am. Chem. Soc. 2017, 27, 139, 9104-9107
获奖及荣誉
国家级青年人才计划入选者，湖南省优秀博士论文
