张鹏晖

张鹏晖


  • 电子邮件:zhangpenghui@him.cas.cn

个人简历

2015-2020年任西安交通大学讲师和副教授,2018年在美国佛罗里达大学进行访问学习,2020年加入中国科学院杭州医学研究所,获国家级青年人才项目(2021)和浙江省卫生高层次创新人才项目(2021)支持。

研究方向

化学、药学、生命科学

承担科研项目情况

入选国家高层次人才特殊支持计划青年拔尖人才项目计划,获得2021年度浙江省卫生创新人才项目支持。研究方向为可编码分子药物、核酸药物与纳米药物、肿瘤疫苗与免疫调控、T细胞分析与工程化增强。以第一作者及通讯作者在Nature Chemistry、JACS、Angew、Advanced Materials等发表论文30余篇,其中5篇入选ESI高被引文章,总被引用3000余次。主持国家自然科学基金青年、面上、重大研究计划培育、专项项目,科技部重大研究计划子课题等省部级项目10余项。

代表论著

(36) Jiang, S.#; Lv, X.#; Ouyang, Z.#; Chi, H.; Zeng, Y.; Wang, Y.; He, J.; Chen, J.; Chen, J.; An, K.; Cheng, M.; Wen, Y.; Li, J.; Zhang, P.* Programmable Circular Multivalent Nanobody‐Targeting Chimeras (mNbTACs) for Multireceptor‐Mediated Protein Degradation and Targeted Drug Delivery. Angewandte Chemie, International Edition 2024, e202407986. https://doi.org/10.1002/anie.202407986. (35) Ying, S.#; Chi, H.#; Wu, X.#; Zeng, P.; Chen, J.; Fu, T.; Fu, W.; Zhang, P.*; Tan, W.* Selective and Orally Bioavailable C-Met PROTACs for the Treatment of c-Met-Addicted Cancer. Journal of Medicinal Chemistry 2024, 67 (19), 17053–17069. https://doi.org/10.1021/acs.jmedchem.3c02417. (34) Dong, L.#; Deng, X. #; Li, Y. #; Zhu, X.; Shu, M.; Chen, J.; Luo, H.; An, K.; Cheng, M.; Zhang, P.*; Tan, W.* Stimuli-Responsive mRNA Vaccines to Induce Robust CD8 + T Cell Response via ROS-Mediated Innate Immunity Boosting. Journal of the American Chemical Society 2024, 146 (28), 19218–19228. https://doi.org/10.1021/jacs.4c04331. (33) Hu, X.; Chi, H.; Fu, X.; Chen, J.; Dong, L.; Jiang, S.; Li, Y.; Chen, J.; Cheng, M.; Min, Q.*; Tian, Y.*; Zhang, P.* Tunable Multivalent Aptamer-Based DNA Nanostructures To Regulate Multiheteroreceptor-Mediated Tumor Recognition. Journal of the American Chemical Society 2024, 146 (4), 2514–2523. https://doi.org/10.1021/jacs.3c10704. (32) Liu, R.; Liu, Z.; Chen, M.; Xing, H.; Zhang, P.*; Zhang, J.* Cooperatively Designed Aptamer-PROTACs for Spatioselective Degradation of Nucleocytoplasmic Shuttling Protein for Enhanced Combinational Therapy. Chemical Science 2023, 15 (1), 134–145. https://doi.org/10.1039/d3sc04249a. (31) An, K.#; Deng, X.#; Chi, H.; Zhang, Y.; Li, Y.; Cheng, M.; Ni, Z.; Yang, Z.; Wang, C.; Chen, J.; Bai, J.; Ran, C.; Wei, Y.; Li, J.; Zhang, P.*; Xu, F.*; Tan, W.* Stimuli-Responsive PROTACs for Controlled Protein Degradation. Angewandte Chemie, International Edition 2023, 62 (39), e202306824. https://doi.org/10.1002/anie.202306824. (30) Chen, Y.#; Gu, L.#; Ma, B.; Li, X.; Mei, Y.; Zhou, J.; Chong, Y.; Ma, M.; Zhang, M.; Wang, L.; Cheng, Y.; Wu, K.; Zeng, J.; Cheng, M.; Guo, P.*; Zhang, P.*; He, D.* Photoactivatable Metal Organic Framework for Synergistic Ferroptosis and Photodynamic Therapy Using 450 Nm Laser. Chemical Engineering Journal 2023, 454 (15), 140438. https://doi.org/10.1016/j.cej.2022.140438. (29) Zhang, C.#; Zhang, P.#; Ren, H.#; Jia, P.; Ji, J.; Cao, L.; Yang, P.; Li, Y.; Liu, J.; Li, Z.; You, M.; Duan, X.; Hu, J.; Xu, F*. Synthetic Biology-Powered Biosensors Based on CRISPR/Cas Mediated Cascade Signal Amplification for Precise RNA Detection. Chemical Engineering Journal 2022, 446 (15), 136864. https://doi.org/10.1016/j.cej.2022.136864. (28) Liu, J.; Zhang, C.; Cao, L.; You, M.; Li, Z.; Guo, H.; Yao, C.; Lou, J.; Zhang, P.*; Xu, F.* Ultrasensitive Multiplexed Detection of Small Molecules and Enzymes Using Stimuli-Responsive Nucleic Acids. Chemical Engineering Journal 2022, 440 (15), 135797. https://doi.org/10.1016/j.cej.2022.135797. (27) Li, J.; Luo, M.; Jin, C.; Zhang, P.; Yang, H.*; Cai, R.*; Tan, W. Plasmon-Enhanced Electrochemiluminescence of PTP-Decorated Eu MOF-Based Pt-Tipped Au Bimetallic Nanorods for the Lincomycin Assay. ACS Applied Materials and Interfaces 2022, 14 (1), 383–389. https://doi.org/10.1021/acsami.1c21528. (26) Luo, C.; He, L.; Chen, F.; Fu, T.; Zhang, P.; Xiao, Z.; Liu, Y.*; Tan, W.* Stimulus-Responsive Nanomaterials Containing Logic Gates for Biomedical Applications. Cell Reports Physical Science 2021, 2 (2). https://doi.org/10.1016/j.xcrp.2021.100350. (25) Zhang, P.#; Gao, D.#; An, K.#; Shen, Q.; Wang, C.; Zhang, Y.; Pan, X.; Chen, X.; Lyv, Y.; Cui, C.; Liang, T.; Duan, X.; Liu, J.; Yang, T.; Hu, X.; Zhu, J.*; Xu, F.*; Tan, W.* A Programmable Polymer Library That Enables the Construction of Stimuli-Responsive Nanocarriers Containing Logic Gates. Nature Chemistry 2020, 12 (4), 381–390. https://doi.org/10.1038/s41557-020-0426-3. (24) Zheng, F.; Wang, C.; Meng, T.; Zhang, Y.; Zhang, P.; Shen, Q.; Zhang, Y.; Zhang, J.; Li, J.; Min, Q.*; Chen, J.*; Zhu, J.* Outer-Frame-Degradable Nanovehicles Featuring Near-Infrared Dual Luminescence for in Vivo Tracking of Protein Delivery in Cancer Therapy. ACS Nano 2019, 13 (11), 12577–12590. https://doi.org/10.1021/acsnano.9b03424. (23) Zhang, P.; An, K.; Duan, X.; Xu, H.; Li, F.; Xu, F.* Recent Advances in siRNA Delivery for Cancer Therapy Using Smart Nanocarriers. Drug Discovery Today 2018, 23 (4), 900–911. https://doi.org/10.1016/j.drudis.2018.01.042. (22) Yang, L.; Sun, H.; Liu, Y.; Hou, W.; Yang, Y.; Cai, R.; Cui, C.; Zhang, P.; Pan, X.; Li, X.; Li, L.; Sumerlin, B.*; Tan, W.* Self-Assembled Aptamer-Grafted Hyperbranched Polymer Nanocarrier for Targeted and Photoresponsive Drug Delivery. Angewandte Chemie, International Edition 2018, 57 (52), 17048–17052. https://doi.org/10.1002/anie.201809753. (21) Li, L.; Jiang, Y.; Cui, C.; Yang, Y.; Zhang, P.; Stewart, K.; Pan, X.; Li, X.; Yang, L.; Qiu, L.; Tan, W.* Modulating Aptamer Specificity with pH-Responsive DNA Bonds. Journal of the American Chemical Society 2018, 140 (41), 13335–13339. https://doi.org/10.1021/jacs.8b08047. (20) He, Z.; Zhang, P.; Xiao, Y.; Li, J.; Yang, F.; Liu, Y.; Zhang, J.*; Zhu, J.* Acid-Degradable Gadolinium-Based Nanoscale Coordination Polymer: A Potential Platform for Targeted Drug Delivery and Potential Magnetic Resonance Imaging. Nano Research 2018, 11 (2), 929–939. https://doi.org/10.1007/s12274-017-1705-1. (19) He, Z.#; Xiao, Y.#; Zhang, J.-R.*; Zhang, P.*; Zhu, J.* In Situ Formation of Large Pore Silica-MnO2 Nanocomposites with H+/H2O2 Sensitivity for O2-Elevated Photodynamic Therapy and Potential MR Imaging. Chemical Communications 2018, 54 (24), 2962–2965. https://doi.org/10.1039/c7cc09532e. (18) Zheng, F.; Zhang, P.; Xi, Y.; Huang, K.; Min, Q.*; Zhu, J.* Peptide-Mediated Core/Satellite/Shell Multifunctional Nanovehicles for Precise Imaging of Cathepsin B Activity and Dual-Enzyme Controlled Drug Release. NPG Asia Materials 2017, 9 (3), e366. https://doi.org/10.1038/am.2017.42. (17) Zheng, F.#; Zhang, P.#; Xi, Y.; Chen, X.; He, Z.; Meng, T.; Chen, J.; Li, L.*; Zhu, J.* Hierarchical Nanocarriers for Precisely Regulating the Therapeutic Process via Dual-Mode Controlled Drug Release in Target Tumor Cells. ACS Applied Materials and Interfaces 2017, 9 (42), 36655–36664. https://doi.org/10.1021/acsami.7b12251. (16) Zhang, P.#; Wang, Y.#; Lian, J.#; Shen, Q.; Wang, C.; Ma, B.; Zhang, Y.; Xu, T.; Li, J.; Shao, Y.; Xu, F.*; Zhu, J.* Engineering the Surface of Smart Nanocarriers Using a pH-/Thermal-/GSH-Responsive Polymer Zipper for Precise Tumor Targeting Therapy In Vivo. Advanced Materials 2017, 29 (36), 1702311. https://doi.org/10.1002/adma.201702311. (15) Ma, L.#; Zhou, H.#; Sun, Y.#; Xin, S.; Xiao, C.; Kumatani, A.; Matsue, T.; Zhang, P.; Ding, S.*; Li, F.* Nanosheet-Structured NiCoO2/Carbon Nanotubes Hybrid Composite as a Novel Bifunctional Oxygen Electrocatalyst. Electrochimica Acta 2017, 252, 338–349. https://doi.org/10.1016/j.electacta.2017.08.192. (14) Zhao, J.#; Zhang, P.#; He, Z.; Min, Q.; Abdel-Halim, E.; Zhu, J.* Thermal-Activated Nanocarriers for the Manipulation of Cellular Uptake and Photothermal Therapy on Command. Chemical Communications 2016, 52 (33), 5722–5725. https://doi.org/10.1039/c6cc01162d. (13) Zhang, P.#; Wang, C.#; Zhao, J.; Xiao, A.; Shen, Q.; Li, L.; Li, J.; Zhang, J.; Min, Q.*; Chen, J.*; Chen, H.; Zhu, J.* Near Infrared-Guided Smart Nanocarriers for MicroRNA-Controlled Release of Doxorubicin/siRNA with Intracellular ATP as Fuel. ACS Nano 2016, 10 (3), 3637–3647. https://doi.org/10.1021/acsnano.5b08145. (12) He, Z.; Zhang, P.; Li, X.; Zhang, J.*; Zhu, J.* A Targeted DNAzyme-Nanocomposite Probe Equipped with Built-in Zn2+ Arsenal for Combined Treatment of Gene Regulation and Drug Delivery. Scientific Reports 2016, 6, 22737. https://doi.org/10.1038/srep22737. (11) Zheng, F.; Zhang, P.; Xi, Y.; Chen, J.; Li, L.*; Zhu, J.* Aptamer/Graphene Quantum Dots Nanocomposite Capped Fluorescent Mesoporous Silica Nanoparticles for Intracellular Drug Delivery and Real-Time Monitoring of Drug Release. Analytical Chemistry 2015, 87 (23), 11739–11745. https://doi.org/10.1021/acs.analchem.5b03131. (10) Zhang, P.; He, Z.; Wang, C.; Chen, J.; Zhao, J.; Zhu, X.; Li, C.; Min, Q.*; Zhu, J.* In Situ Amplification of Intracellular Microrna with Mnazyme Nanodevices for Multiplexed Imaging, Logic Operation, and Controlled Drug Release. ACS Nano 2015, 9 (1), 789–798. https://doi.org/10.1021/nn506309d. (9) Cao, J.; Zhang, P.; Liu, Y.; Abdel-Halim, E.; Zhu, J.* Versatile Microfluidic Platform for the Assessment of Sialic Acid Expression on Cancer Cells Using Quantum Dots with Phenylboronic Acid Tags. ACS Applied Materials and Interfaces 2015, 7 (27), 14878–14884. https://doi.org/10.1021/acsami.5b03519. (8) Zhang, P.#; Cheng, F.#; Zhou, R.; Cao, J.; Li, J.; Burda, C.; Min, Q.*; Zhu, J.* DNA-Hybrid-Gated Multifunctional Mesoporous Silica Nanocarriers for Dual-Targeted and microRNA-Responsive Controlled Drug Delivery. Angewandte Chemie, International Edition 2014, 53 (9), 2371–2375. https://doi.org/10.1002/anie.201308920. (7) Zhang, P.; Cao, J.; Min, Q.; Zhu, J.* Multi-Shell Structured Fluorescent-Magnetic Nanoprobe for Target Cell Imaging and on-Chip Sorting. ACS Applied Materials and Interfaces 2013, 5 (15), 7417–7424. https://doi.org/10.1021/am401740a. (6) Sun, D.; Ban, R.; Zhang, P.; Wu, G.; Zhang, J.*; Zhu, J.* Hair Fiber as a Precursor for Synthesizing of Sulfur- and Nitrogen-Co-Doped Carbon Dots with Tunable Luminescence Properties. Carbon 2013, 64, 424–434. https://doi.org/10.1016/j.carbon.2013.07.095. (5) Li, J.; Wang, W.; Sun, D.; Chen, J.; Zhang, P.; Zhang, J.; Min, Q.*; Zhu, J.* Aptamer-Functionalized Silver Nanoclusters-Mediated Cell Type-Specific siRNA Delivery and Tracking. Chemical Science 2013, 4 (9), 3514–3521. https://doi.org/10.1039/c3sc51538a. (4) Dong, S.*; Zhang, P.; Yang, Z.; Huang, T. Simultaneous Determination of Catechol and Hydroquinone by Carbon Paste Electrode Modified with Hydrophobic Ionic Liquid-Functionalized SBA-15. Journal of Solid State Electrochemistry 2012, 16 (12), 3861–3868. https://doi.org/10.1007/s10008-012-1805-5. (3) Cao, J.; Chen, Z.; Hao, X.; Zhang, P.; Zhu, J.* Quantum Dots-Based Immunofluorescent Microfluidic Chip for the Analysis of Glycan Expression at Single-Cells. Analytical Chemistry 2012, 84 (22), 10097–10104. https://doi.org/10.1021/ac302609y. (2) Dong, S.*; Zhang, P.; Liu, H.; Li, N.; Huang, T. Direct Electrochemistry and Electrocatalysis of Hemoglobin in Composite Film Based on Ionic Liquid and NiO Microspheres with Different Morphologies. Biosensors and Bioelectronics 2011, 26 (10), 4082–4087. https://doi.org/10.1016/j.bios.2011.03.039. (1) Zhang, P.; Dong, S.*; Gu, G.; Huang, T. Simultaneous Determination of Cd2+, Pb2+, Cu2+ and Hg2+ at a Carbon Paste Electrode Modified with Ionic Liquid-Functionalized Ordered Mesoporous Silica. Bulletin of the Korean Chemical Society 2010, 31 (10), 2949–2954. https://doi.org/10.5012/BKCS.2010.31.10.2949.

获奖及荣誉

用于递送活性成分的脂质分子及其组合物的制备和应用 公告号:CN115286523B 申请日期:20220715 授权日期:20240319 申请人:中国科学院基础医学与肿瘤研究所(筹) 发明人:谭蔚泓 张鹏晖 李岩 邓旭倩 符婷 谢斯滔 甘绍举 刘湘圣 程明 逯良伟 一种双价可电离脂质化合物、组合物及其应用 公告号:CN114213346B 申请日期:20220222 授权日期:20220520 申请人:中国科学院基础医学与肿瘤研究所(筹) 发明人:谭蔚泓 张鹏晖 李岩 邓旭倩 符婷 谢斯滔 甘绍举 一种双价可电离脂质化合物、组合物及其应用 公告号:CN114213347B 申请日期:20220222 授权日期:20220520 申请人:中国科学院基础医学与肿瘤研究所(筹) 发明人:谭蔚泓 张鹏晖 李岩 邓旭倩 符婷 谢斯滔 甘绍举