国家优秀青年科学基金获得者，浙江省青年拔尖人才，北京大学-清华大学生命科学联合中心杰出博士后。中华医学会糖尿病学分会糖尿病胰岛调控与再生医学学组委员。专注于研究细胞命运重编程、人多能干细胞定向分化、细胞替代治疗、疾病模型构建。 工作经历： 2023.08至今 中国科学院杭州医学研究所 研究员 2017.04至2023.02 杭州瑞普晨创科技有限公司 首席技术官/项目负责人 2015.04 至 2017.03 北京大学 化学学院 博士后

干细胞再生医学、细胞替代治疗、疾病模型构建

1. 主持 国家自然科学基金委 GJYQ项目 2. 主持 中国科学院上海分院 抢占制高点青年攀登计划 3. 主持 浙江省科技厅 浙江省“尖兵”“领雁”重点研发计划 4. 主持 浙江省科技厅 浙江省“万人计划'青年拔尖人才项目

1.Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient. Cell. 2024 Sep 20:S0092-8674(24)01022-5. Wang S*, Du Y*, Zhang B*, Meng G*, Liu Z*, Liew SY*, Liang R*, Zhang Z*, Cai X*, Wu S*, Gao W*, Zhuang D, Zou J, Huang H, Wang M, Wang X, Wang X, Liang T, Liu T, Gu J, Liu N, Wei Y, Ding X, Pu Y, Zhan Y, Luo Y, Sun P, Xie S, Yang J, Weng Y, Zhou C, Wang Z, Wang S, Deng H#, Shen Z#. 2.Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells. Cell Stem Cell. 2024 Jun 6;31(6):850-865.e10. Hua H*, Wang Y*, Wang X*, Wang S, Zhou Y, Liu Y, Liang Z, Ren H, Lu S, Wu S, Jiang Y, Pu Y, Zheng X, Tang C, Shen Z, Li C#, Du Y#, Deng H#. 3.Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem-cell-derived islets. Nat Metab. 2023 Jan;5(1):29-40. Liang Z*, Sun D*, Lu S*, Lei Z, Wang S, Luo Z, Zhan J, Wu S, Jiang Y, Lu Z, Sun S, Shi Y, Long H, Wei Y, Yu W, Wang Z, Yi LS, Zhang Y, Sun W, Fang X, Li Y, Lu S, Lv J, Sui W, Shen Z, Peng X#, Du Y#, Deng H#. 4.Chemical reprogramming of melanocytes to skeletal muscle cells. J Cachexia Sarcopenia Muscle. 2023 Apr;14(2):903-914. Yang W*, Wang Y*, Du Y*, Li J, Jia M, Li S, Ma R, Li C, Deng H#, Hu P#. 5.Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates. Nat Med. 2022 Feb;28(2):272- 282. Du Y*, Liang Z*, Wang S*, Sun D*, Wang X*, Liew SY*, Lu S*, Wu S, Jiang Y, Wang Y, Zhang B, Yu W, Lu Z, Pu Y, Zhang Y, Long H, Xiao S, Liang R, Zhang Z, Guan J, Wang J, Ren H, Wei Y, Zhao J, Sun S, Liu T, Meng G, Wang L, Gu J, Wang T, Liu Y, Li C, Tang C, Shen Z#, Peng X#, Deng H#. 6.Long-term functional maintenance of primary human hepatocytes in vitro. Science. 2019 Apr 26;364(6438):399-402. Xiang C*, Du Y*, Meng G*, Soon Yi L, Sun S, Song N, Zhang X, Xiao Y, Wang J, Yi Z, Liu Y, Xie B, Wu M, Shu J, Sun D, Jia J, Liang Z, Sun D, Huang Y, Shi Y, Xu J, Lu F, Li C, Xiang K, Yuan Z#, Lu S#, Deng H#. 7.A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts. Cell Res. 2019 Sep;29(9):696-710. Xie B*, Sun D*, Du Y*, Jia J, Sun S, Xu J, Liu Y, Xiang C, Chen S, Xie H, Wang Q, Li G, Lyu X, Shen H, Li S, Wu M, Zhang X, Pu Y, Xiang K, Lai W, Du P, Yuan Z, Li C, Shi Y#, Lu S#, Deng H#. 8.Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming. Cell Stem Cell. 2014 Mar 6;14(3):394-403. Du Y*, Wang J*, Jia J*, Song N*, Xiang C*, Xu J, Hou Z, Su X, Liu B, Jiang T, Zhao D, Sun Y, Shu J, Guo Q, Yin M, Sun D, Lu S#, Shi Y#, Deng H#. 9.Direct lineage reprogramming: strategies, mechanisms, and applications. Cell Stem Cell. 2015 Feb 5;16(2):119-34. Xu J, Du Y, Deng H#.

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